QUANTITATIVE STRUCTURAL AND FUNCTIONAL IMAGING OF THE LUNG

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 本项目的重点是利用超极化的~3He核磁共振对结构进行系统的研究 以及健康和疾病受试者的肺功能。该项目还将延长 超极化气体的产生和成像方法，目的是使3He磁共振成像 实用研究和临床工具。最直接的目标是描述进程的特征 随时间推移的3He成像评估，并确定这些评估中哪些具有潜在的 目的：检测慢性阻塞性肺疾病(COPD)的早期。它还将尝试 应用一种最新开发的方式，用超极化3He磁共振成像肺的局部结构和功能，以获得对COPD进展的新见解。这项技术将被用于 跟踪100名受试者在五年内的肺结构和功能的演变。 该项目进一步计划在过去十年通过使用3He MRI获得的技能的基础上 从根本上获得关于结构和气体局部变化的新的详细信息- 临床诊断为COPD的受试者和COPD高危受试者(健康吸烟者)的肺交换效率。慢性阻塞性肺疾病的严重程度和疾病进展的研究 使用最近实施的测量局部氧分压(PAO2)的方法 并计算了超极化气体在体内的表观扩散系数。作为一部分 在这个项目中，尚未被诊断为糖尿病的吸烟者的这些参数的变化 随着时间的推移，将对肺部疾病进行监测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project focuses on the use of hyperpolarized 3He MRI for the systematic study of the structure and function of the lung in healthy and diseased human subjects. This project will also extend the methods of hyperpolarized gas production and imaging with the goal of making 3He MRI a more practical research and clinical tool. The most immediate objective is to characterize the progression of 3He imaging assessments over time and to identify which of those assessments have the potential to detect the early stages of Chronic Obstructive Pulmonary Disease (COPD). It will also attempt to apply a recently developed modality, imaging of the regional structure and function of the lung with hyperpolarized 3He MRI, to gain new insight into COPD progression. This technique will be used to track the evolution of pulmonary structure and function in 100 subjects over a period of five years. This project further plans to build on the skills gained over the past decade by using 3He MRI to obtain fundamentally new, detailed information about localized changes in the structure and gas- exchange efficiency of the lungs of subjects with clinically diagnosed COPD and subjects at risk for developing COPD (healthy smokers). The degree of COPD and study the progression of the disease using recently implemented methods for measuring the regional partial pressure of oxygen (PAO2) and the apparent diffusion coefficient (ADC) of hyperpolarized gas in vivo will be evaluated. As part of this project the change of these parameters in smokers who have not yet been diagnosed with lung disease will be monitored over time.