CHARACTERIZE THE FUNCTION OF PROTEIN TYROSINE PHOSPHATASE PTPMT1 IN MITOCHONDRIA

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 PTPMT1是第一个定位于线粒体内膜的蛋白酪氨酸磷酸酶。我们最近的工作表明，PTPMT1对于线粒体的完整性和最佳功能是必需的。我们与NCMIR合作，其研究人员进行电子显微镜和电子断层扫描，以进一步表征线粒体中PTPMT1的功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. PTPMT1 was the first protein tyrosine phosphatase found to localize to the inner membrane of mitochondria. Our recent work has suggested that PTPMT1 is required for the integrity and optimal function of mitochondria. We collaborate with NCMIR whose researchers perform electron microscopy and electron tomography to further characterize the function of PTPMT1 in mitochondria.