INVESTIGATING EARLY ULTRASTRUCTURAL CHANGES IN THE PATHOGENESIS OF HYDROCEPHALUS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们建立了一种新的可诱导的小鼠脑积水模型，外显率为100%。因此，我们有独特的能力来研究脑积水发展过程中的早期病原学变化。通过使用电子显微镜，我们希望阐明导致脑积水发展的早期超微结构变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have developed a novel inducible mouse model of hydrocephalus with 100% penetrance. As a result, we have the unique ability to investigate early pathogenic changes in the development of hydrocephalus. Through the use of electron microscopy, we hope to elucidate early ultrastructural changes that lead to the development of hydrocephalus.