ROUTINE NMR FOR CHARCATERIZATION OF ORGANIC CHEMICALS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 蛋白质的氨基酸序列编码其三维结构，这种结构体现在生物功能上。利用从合成化学到生物化学再到细胞生物学的各种技术，Raines团队正在从原子细节上阐明蛋白质结构和功能的化学基础和生物学目的。Raines小组的努力正在深入了解氨基酸序列与蛋白质功能(或功能障碍)之间的关系，并创造出具有理想特性的新分子。这包括用于蛋白质修饰、蛋白质/肽合成和物理有机研究的有机小分子的合成。要对这些有机小分子进行表征，需要进行质子、碳和磷核磁共振实验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The amino acid sequence of a protein encodes its three-dimensional structure, and this structure manifests itself in biological function. Using techniques that range from synthetic chemistry to biochemistry to cell biology, the Raines group is illuminating in atomic detail both the chemical basis and the biological purpose for protein structure and protein function. The efforts of the Raines group are leading to insights into the relationship between amino acid sequence and protein function (or dysfunction), as well as to the creation of novel molecules with desirable properties. This involves syntheses of small organic molecules for protein modification, protein/peptide synthesis and physical organic studies. Proton, carbon and phosphorus NMR experiments are required for characterization of these small organic molecules.