DEVELOPMENT OF A DOSI INSTRUMENT WITH SUPERCONTINUUM LIGHT SOURCES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 目前，DOS需要光源的组合来照射650-1000 nm的组织。 对于FDPM而言，在可见光波长中几乎没有实用的激光二极管。 新的超连续光纤激光器为这两个问题提供了解决方案：具有高可见光和近红外光谱含量的集成光源。 高谐波含量（5 ps主脉冲宽度），高密度功率（~ 1 mW/nm）和交钥匙操作使这些光源适合实时频域宽带光谱成像。 我们建议将超连续谱技术集成到DOS/I仪器中，该仪器将允许使用各种基于光纤的探针进行扩展的宽带光谱（400-1100 nm）和时间（~几GHz调制）光谱成像，这些探针设计用于跨空间尺度询问组织。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Currently DOS requires a combination of light sources to illuminate tissues from 650-1000 nm. Few practical laser diodes exist in visible wavelengths for FDPM. New supercontinuum fiber lasers offer solutions to both problems: an integrated source with high visible and NIR spectral content. The high harmonic content (5 ps master pulse width), high density power (~ 1mW/nm) and turnkey operation make these light sources amenable to real-time frequency-domain broadband spectral imaging. We propose to integrate supercontinuum technology into DOS/I instrumentation that will allow for extended broadband spectral (400-1100 nm) and temporal (~ few GHz modulation) spectroscopic imaging using a variety of fiber-based probes designed to interrogate tissues across spatial scales.