STRUCTURAL GENOMICS FOR DIFFICULT TARGETS AND/OR DISEASE-RELATED PROTEINS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 结构基因组学已经到了一个重点已经转移到为生物界做出更实质性贡献的时代。我们集团运营着两个PSI-II中心的X射线结晶学设施？结构和功能创新综合中心(ISFI)和结核病结构基因组学联盟(TBSGC)。这两个中心专注于开发技术来解决重要但困难的靶标(ISFI)的晶体结构，以及解决结核分枝杆菌的重要药物靶标的晶体结构。由于靶材的难度，大多数晶体都很难获得，而且往往很小。为蛋白质结晶学优化的管理良好和高强度的同步加速器源通常是进行有效的衍射实验的唯一希望。表征和解决这些具有生物医学意义的蛋白质的晶体结构将给生物界带来实质性的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Structural genomics has reached an era where focus has been shifted to making more substantial contribution to the biological community. Our group operates the x-ray crystallography facility of two PSI-II centers ? the Integrated Center for Structure and Function Innovation (ISFI) and the TB Structural Genomics Consortium (TBSGC). The two centers focus on develop technologies to solve crystal structures of important but difficult targets (ISFI), and to solve those of important drug targets of Mycobacterium tuberculosis. Because of the difficulty of the targets, most of the crystals are difficult to obtain and often very small. Well managed and intense synchrotron sources optimized for protein crystallography are usually the only hope in conducting effective diffraction experiments. Characterizing and solving the crystal structures of these proteins of biomedical importance will bring substantial impact to the biological community.