PROTEOMIC CHANGES IN MUSCLE CELLS WITH PULMONARY HYPERTENSION

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 肺动脉高压（Pulmonary arterial hypertension，PAH）是一种严重的疾病，通常会导致死亡。目前尚无可靠的治疗方法，主要原因是PAH的生化病因和病程尚不清楚，也没有足够的动物模型。我们正在对受影响个体的组织进行蛋白质组学研究，以获得有关与疾病相关的途径的知识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Pulmonary arterial hypertension (PAH) is a devastating disease with a usually fatal outcome There is as yet no reliable treatment for PAH, largely because the biochemical cause and course remain unknown.There are no adequate animal models. We are undertaking proteomics investigations of tissues from affected individuals, in order to gain knowledge about the pathways that are affected in conjunction with the disease.