PIG TO NON-HUMAN PRIMATE ISLET XENOGRAFTS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项资助研究的长期目标是治疗I型糖尿病，并利用胰岛细胞异种移植预防其破坏性并发症。通过三项资助项目的资助，我们正在积极探索使用猪胰岛作为人类胰岛移植的替代方案，以逆转人类的糖尿病。在CMRR和明尼苏达大学糖尿病免疫与移植研究所(DIIT)的合作中，我们的目标是1)通过超高场磁共振(UHF)测量移植部位的血管形成来评估移植部位的就绪性和/或适宜性，以及2)使用磁共振波谱方法评估移植前后胰岛的存活情况。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The long-term objective of this funded research is to treat type I Diabetes and to prevent its devastating complications using islet-cell xeno transplantation. Through the three funded program project grants we are actively exploring the use of porcine islets as an alternative to human islets for transplantation to reverse diabetes in humans. In this collaboration between the CMRR and the Diabetes Institute for Immunology and Transplantation (DIIT) at U of MN, our goal is to 1) assess the readiness and/or suitability of the transplantation site by measuring the vascularization with ultra high field (UHF) MRI and 2) assess the pre- and post-transplant viability of islets using magnetic resonance spectroscopy methods.