NEURAL CORRELATES OF EXECUTIVE FUNCTION AND EMOTION IN ADOLESCENCE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 参赛者包括14名20-22岁的成年人和16名13-14岁的青少年。 扫描过程将以矢状面侦察开始，以便指定后续图像。将获取矢状面T1MPRAGE图像用于功能图像的联合配准。当受试者执行下面的行为任务时，全脑EPI大胆图像将在三次运行中获得。将以相同的分辨率和切片位置获取EPI场地图，以允许离线校正场不均匀。 这一行为将GO/NOGO任务与从国际情感图片系统中挑选出来的情感唤醒背景图片结合在一起。在这项任务中，字母按顺序放在计算机屏幕中央的一个小方框中。受试者被要求尽可能快地按下按钮，回答一系列字母中的每一个，但不包括一个特定的目标：X。X出现在25%的试验中，因此参与者获得了一种强烈的按压倾向，并需要在NOGO试验期间积极抑制他们的反应。行为任务由十二个块的三次运行组成。响应(按下或不按下)和反应时间将使用MRI兼容按钮框记录下来。 我们预计，每个主题的整个会议时间为一个小时。这一估计包括15分钟的设备设置和参与者定位、11分钟的结构扫描、30分钟的功能扫描和10分钟的清理和数据传输。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Participants will be 14 adults between the ages of 20-22 years and 16 teens between the ages of 13-14 years. The scanning session will begin with a sagittal scout for purposes of prescribing subsequent images. Sagittal T1 MPRAGE images will be aquired for coregistration of functional images. Whole brain EPI BOLD images will be acquired in three runs while subjects perform the behavioral task below. An EPI fieldmap will be acquired at the same resolution and slice locations to allow for offline correction of field inhomogeneities. The behavioral combines a go/nogo task with emotionally arousing background images selected from the International Affective Picture System. In this task, letters are presented sequentially in a small box at the center of the computer screen. Subjects are asked to respond as quickly as possible with a button press to every one of a series of letters except for a specific target: an 'X'. The Xs appear on 25% of trials such that participants acquire a prepotent tendency to press and need to actively inhibit their response during nogo trials. The behavioral task consists of three runs of twelve blocks. Responses (press or no press) and reaction times will be recorded using an MRI compatible button box. We anticipate the entire session taking one hour per subject. This estimate includes 15 minutes for equipment setup and positioning of the participant, 11 minutes of structural scanning, 30 minutes of functional scanning and 10 minutes of clean-up and data transfer.