CORTICAL AND SUBCORTICAL REGIONAL MORPHOLOGY IN UNIPOLAR DEPRESSION

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在单相抑郁症中经常报告明显的区域异常。 然而，由于图像采集的局限性、分析方法的敏感性和样本特征的混淆，证据是混合的。 我们的目的是研究单相抑郁症患者的皮质和皮质下形态，特别是海马体积和次区域形态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Distinct regional abnormalities are frequently reported in unipolar depression. However, the evidence has been mixed due to limitations in the image acquisition, sensitivity of the analysis methods, and confounds in the sample characteristics. Our aim is to examine cortical and subcortical morphology, in particular hippocampal volume and subregional morphology, in patients with unipolar depression.