TRANSDISCIPLINARY IMAGING GENETICS CENTER (RMI)

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 拟议的跨学科成像遗传学中心是一个探索性中心，其首要目标是通过促进一门名为成像遗传学的新学科的发展，提高我们对大脑在健康和疾病中的功能的了解。该中心通过汇集来自加州大学欧文分校和多伦多大学的跨学科专家团队来实现这一目标，这些专家在基因组学、成像分析、统计方法和被视为这一目标关键的互补领域具有经验。这些专家在中心顾问和外部咨询委员会的辅助下，在各自的领域制定了新的方法。该项目的主要重点是开发将成像和基因组学相结合的方法。很明显，精神疾病涉及大脑功能障碍，可以用先进的大脑成像技术进行可视化。精神疾病以及正常的大脑功能也有遗传成分；因此，重要的是要考虑与大脑发育、精神功能和功能障碍相关的基因。将成像数据与人类基因组计划产生的丰富遗传数据相结合，将增强我们对大脑功能和精神疾病的了解。这种整合的价值在我们的初步研究中得到了证明，这些研究证明了大脑新陈代谢、临床反应和DRD1等位基因之间的关联(Potkin等人，2003年)，以及大脑新陈代谢、迟发性运动障碍的风险、抗精神病药物治疗的运动副作用和DRD3等人之间的关联(Potkin等人，2003b，Basile等人，2002年)。该中心建议通过赞助年度国际研讨会以及为这一新兴学科制定和实施路线图或工作计划，促进所涉各领域之间的持续对话。中心的工作计划将以中心调查员、其指导委员会、中心顾问和外部咨询委员会之间的跨学科合作为指导。指导委员会和外部咨询委员会还负责评估中心的研究进展，提出替代解决方案，并指导中心的整体发展。如果该中心的目标得以实现，新兴的基因成像领域将被定位为加强对精神疾病、个体差异以及遗传、环境和大脑功能之间的相互作用等生物学复杂问题的理解。对这些领域的单独研究提供了关于大脑功能障碍的重要启示。然而，它们的融合和互动将提供其他方式无法获得的新知识。如果没有一个专注于单一综合主题的统一中心，这些目标就不可能实现。该中心产生的新知识为改善精神疾病的诊断和治疗带来了相当大的希望。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overriding goal of the proposed Transdisciplinary Imaging Genetics Center, an exploratory center, is to enhance our understanding of brain function in health and disease, through facilitation of development of a new discipline, referred to as imaging genetics. The Center does this by assembling an interdisciplinary team of experts from U.C. Irvine and the University of Toronto with experience in genomics, imaging analysis, statistical methods, and complementary areas viewed as key to this goal. These experts, complemented by the Center's consultants and External Advisory Board, have developed novel methods in their respective fields. The major focus of this project is to develop methods for combining imaging and genomics. It is clear that mental illness involves brain dysfunction that can be visualized with advanced brain imaging techniques. Mental illness as well as normal brain function also has a hereditary component; therefore, it is essential that the genes related to aspects of brain development, mental function and dysfunction, be considered. The integration of the imaging data with the rich genetic data resulting from the human genome project will enhance our understanding of brain function and mental illness. The value of this integration is illustrated in our initial studies that demonstrated an association between brain metabolism, clinical response and DRD1 alleles (Potkin at al, 2003), and between brain metabolism, risk of tardive dyskinesia, a motor side-effect on antipsychotic treatment, and DRD3 alleles (Potkin et al 2003b, Basile et al, 2002). The Center proposes the facilitation of an ongoing dialogue among the various fields involved by sponsoring annual international symposia and the development and implementation of a roadmap or work plan for this emerging discipline. The work plan for the Center will be guided by a transdiscipllnary collaboration between the Center investigators, their Steering Committee, the Center consultants, and the External Advisory Board. The Steering Committee and External Advisory Board are also charged with evaluating the Center's research progress and suggesting alternative solutions, as well as guiding the overall development of the Center. If the aims of the Center are achieved, the emerging field of genetic imaging will be positioned to enhance understanding of the biologically complex problem of mental illness, individual differences, and the interplay between genetics, environment, and brain function. Study of these fields individually has provided important revelations regarding brain dysfunction. Their integration and interaction, however, will provide new knowledge that would not be otherwise available. These goals could not be achieved without a unifying Center focused on a single integrative theme. The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness.