SIMULATION OF ELECTRIC STIMULATION FOR BONE GROWTH

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 背景： 战场上医疗保健和后送战略的改进导致 越来越多的退伍军人在与战争有关的灾难性伤害中幸存下来。而当 提高存活率是医学上的进步，许多老兵从战斗中归来 截肢需要复杂的后续护理，广泛的康复，以及 昂贵的假肢服务。骨融合是一种外科手术，它可以直接提供 植入物和宿主组织之间骨骼连接在牙科领域已被证明是成功的， 耳廓和股骨头植入物。然而，使用自然生物的一个挑战是 固定是在种植体界面处获得强大的骨骼联锁，这是 长期种植功能。因此，这项研究的目标是在 以前，电诱导骨生长用于增加骨折的临床成功 治疗，并扩大这项技术，以改善截肢者的骨整合。 基本原理： 为了验证电刺激将增加骨骼的普遍假设 附件，设计了一个分两个阶段的项目，利用体外、体内和体内 确认这项技术的安全性和有效性的硅胶模式 在退伍军人和勇士截肢者中实施。该模型的具体假设 均建立在组织学评估、力学测试和有限元分析的基础上。 具体地说，基于有限元的退伍军人截肢者仿真分析 计算机断层扫描显示残肢安全有效 密度和电场将在骨-种植体界面处获得。 问题： 虽然在这方面已经取得了很大的进展，但还有许多其他 中心未来需要解决的障碍。具体的例子如下 挑战包括基于图像的建模、不确定性可视化、详细模拟、 和估计精度。 设计与方法： 该中心与DBP合作的主要目标是开发一个全面的和 经过验证的计算基础设施，将支持创建特定于患者的 截肢者残肢模型辅助评估和治疗 骨性融合的方法。该DBP是基于图像的建模的另一个例子 作为中心研究和研究的中心框架的模拟管道 发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: Improvements in medical care and evacuation strategies on the field of combat have led to an increased number of veterans surviving disastrous war related injuries. While the improved survival rate is a medical advance, many veterans are returning from combat with amputations that require complex follow-up care, extensive rehabilitation, and expensive prosthetic services. Osseointegration is a surgical procedure that provides direct skeletal attachment between an implant and host tissue with proven success in dental, auricle, and transfemoral implants. However, one challenge with using natural biological fixation is attaining a strong skeletal interlock at the implant interface, a prerequisite for long-term implant function. Therefore, the objective of this study is to build upon the previous, clinical success of electrically induced bone growth used to augment fracture healing, and to expand this technology to improve osseointegration for amputees. Rationale: To validate the general hypothesis that electrical stimulation will increase skeletal attachment, a two-phase project has been designed that utilizes in vitro, in vivo, and in silico modalities to confirm the safety and efficacy of this technology prior to implementation in veteran and warrior amputees. The specific hypotheses for this model are founded on histological assessment, mechanical testing, and finite element analysis. Specifically, finite element-based simulation analysis of veteran and warrior amputee residual limbs imaged with computed tomography scans reveal that safe and effective densities and electric fields will be attainable at the bone-implant interface. Questions: While progress on this DBP has already been substantial, there are many additional hurdles that the Center will need to address in the future. Specific examples of these challenges include image-based modeling, uncertainty visualization, detailed simulation, and estimation accuracy. Design & Methods: The main goal of the Center collaboration with this DBP is to develop a comprehensive and validated computational infrastructure that will support the creation of patient specific models of the residual limbs of amputees to assist in the evaluation and treatment by means of osseointegration. This DBP is another example of the image-based modeling and simulation pipeline that serves as a central framework of the Center's research an development.