SIGNALING AND ACTIN NUCELATION

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 Nck分子已成为受体激活的细胞骨架重组的重要调节剂。特别地，含有nNck结合结构域的受体复合物的聚集在聚集位点产生肌动蛋白聚合的彗星尾。我们将用虚拟细胞来模拟这个系统，试图剖析这种行为背后的复杂信号网络

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Nck molecule has emerged as an important regulator of receptor activated cytoskeletal reorganization. In particular, aggregation of a receptor complex containing a nNck binding domain produces comet tails of actin polymerization at the site of aggregation. We will model this system with the Virtual Cell in an effort to dissect the complex signaling network underlying this behavior