STRUCTURAL AND FUNCTIONAL STUDIES OF BACTERIAL TOXINS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 细菌毒素会引起各种病理效应。本研究拟对部分CDC A类细菌毒素的结构和功能进行研究。主要目的是了解毒素识别和攻击宿主的机制，并开发治疗或预防毒素相关疾病的药物。出于安全考虑，我们正在使用灭活且无毒的转基因毒素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bacterial toxins cause various pathological effects. The current study proposes to investigate the structure and function of selected CDC Category-A bacterial toxins. The primary aim is to understand the mechanism by which toxins recognize and attack their host, and to develop drugs to treat or prevent toxin related illness. Due to the safety concern, we are working with genetically modified forms of toxins that are inactivated and nontoxic.