STRUCTURE OF RECEPTOR COMPLEXES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该项目将使用X射线结晶学研究来确定激活免疫反应的细胞表面蛋白复合体的三维结构。对这些复合体的结构分析将提供关于细胞激活的新信息，并可能导致控制免疫病理的新策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project will use x-ray crystallographic studies to determine the three dimensional structures of cell surface protein complexes, which activate immune responses. Structural analysis of these complexes will provide new information on cellular activation and may lead to novel strategies to control immune pathology.