Alzheimer's Disease Research Center

描述（由申请人提供）：华盛顿大学（UW）阿尔茨海默病研究中心（ADRC）的总体目标是继续提供一个研究环境，以促进获得有关AD和相关神经退行性痴呆疾病病理生物学的新知识，并将这些知识应用于实验疗法的开发。一个由基础和临床研究人员，医疗保健专业人员和行政人员组成的跨学科合作团队支持并开展了一系列富有成效的痴呆症研究和职业发展计划。虽然ADRC附属研究解决AD和其他痴呆症的遗传学将继续，ADRC的主题已重新集中在生物标志物和实验治疗。ADRC通过直接合作和正式的多中心计划，如国家阿尔茨海默氏症协调中心（NACC），阿尔茨海默氏症合作研究（ADCS），综合UW ADRC/俄勒冈州健康与科学大学ADC神经病理学核心，以及晚发型家族性AD倡议的NIA遗传学，支持ADRC内，更大的UW研究社区和国家的富有成效的研究。一个职业发展的环境中，研究员和初级教师获得研究和临床技能是由一个富有成效的试点补助金计划的支持。以前的成就产生了基本的，临床和行为的贡献，了解AD。ADRC提出了五个ADRC核心和三个研究项目：项目1：药物诱导的CNS胰岛素活性增加的CSF结合谱，托马斯J. Montine博士;项目2：鼻内注射地特胰岛素的治疗作用，Suzanne Craft博士;项目3：成人骨髓移植体内A肽蓄积和神经元损伤的调节，C.德克·基恩。

DESCRIPTION (provided by applicant): The overall goal of the University of Washington (UW) Alzheimer's Disease Research Center (ADRC) is to continue to provide a research milieu that facilitates the acquisition of new knowledge about the pathobiology of AD and related neurodegenerative dementing disorders and applies this knowledge to the development of experimental therapeutics. An interdisciplinary collaborative team of basic and clinical investigators, health care professionals, and administrative personnel supports and carries out an array of productive dementia research and career development programs. Although ADRC affiliated research addressing the genetics of AD and other dementing disorders will continue, the ADRC theme has refocused on biomarkers and experimental therapeutics. The ADRC supports productive research within the ADRC, in the greater UW research community and nationally through direct collaborations and formal multi-center programs such as the National Alzheimer's Coordinating Center (NACC), the Alzheimer's Disease Cooperative Study (ADCS), the integrated UW ADRC/Oregon Health and Science University ADC Neuropathology Core, and the NIA genetics of late-onset familial AD initiative. A career development environment in which fellows and junior faculty acquire research and clinical skills is supported by a productive pilot grant program. Previous accomplishments have generated basic, clinical and behavioral contributions to knowledge about AD. The ADRC proposes five ADRC cores and three research projects: Project 1: CSF binding profiling of drug- induced increased CNS insulin activity, Dr. Thomas J. Montine; Project 2: Therapeutic Effects of Intra-Nasal Insulin Detemir, Dr. Suzanne Craft; Project 3: Modulation of A¿ peptide accumulation and neuron damage in vivo with adult bone marrow transplants, Dr. C. Dirk Keene.