Pilot Project

我们酒精研究中心的主要主题是通过研究治疗。通过加强我们对酒精对大脑的作用以及酒精滥用和依赖发展的个人风险因素的基本知识，可以开发出更好的治疗方法。促进酒精研究的这种翻译方法的一个重要方法是鼓励开发新的工具和想法。分子生物学和遗传学，神经科学，心理学，精神病学和相关领域的最新进展为更好地定义过量饮酒的关键机制和途径提供了巨大的希望。反过来，这些目标可以 用于制定有效和个性化的治疗策略。 ARC试点项目的主要目标是识别和招募个人使用这些独特的工具和技能，以产生与酒精治疗相关的新颖和有趣的数据。这一目标将通过实施三个具体目标来实现：1）提供一种机制，以招募和指导基础科学和临床研究人员进入酒精研究领域，并提高他们产生出版物和独立赠款的能力; 2）通过确定基础科学和临床实践重叠的关键领域，加大力度促进和发展酒精研究领域的转化研究方法; 3）找出我们在酒精对大脑和行为影响方面的知识差距，并应用特定的技术和方法来解决这些问题。 每年，我们将邀请整个MUSC校园的研究人员提交一份5页的提案，描述一项专门针对新型酒精治疗或对治疗有影响的研究计划。已经建立了一个审查和选择试点项目供资的制度。将严格监测本构成部分支助的项目的进展情况，并向初级调查员和酒精领域的新手提供指导。通过积极寻求来自MUSC研究人员在大学内的各种学科的试点项目，我们不仅将扩大我们的研究能力，但将提供培训和支持，以调查谁寻求加入我们解决与酗酒和过量饮酒相关的问题。

The major theme of our Alcohol Research Center is treatment through research. By enhancing our basic knowledge of alcohol's action on the brain and of individual risk factors for the development of alcohol abuse and dependence, better treatments can be developed. One important way to facilitate this translation approach to alcohol research is to encourage the development of new tools and ideas. Recent advances in molecular biology and genetics, neuroscience, psychology, psychiatry, and related fields offer great promise for better defining key mechanisms and pathways that underlie excessive drinking. In turn, these targets can be used to develop effective and personalized treatment strategies. The major goal of the ARC Pilot Project Component is to identify and recruit individuals to use these unique tools and skills in order to generate novel and interesting data of relevance to alcohol treatment. This goal will be accomplished by carrying out three Specific Aims: 1) Provide a mechanism to recruit and mentor basic science and clinical investigators into the alcohol research field and to promote their ability to generate publications and independent grant funding; 2) Increase efforts in promoting and developing translational research approaches in the alcohol research field by identifying critical areas where basic science and clinical practice overlap; and 3) Identify gaps in our knowledge regarding the effects of alcohol on brain and behavior, and apply specific technologies and approaches to solving these problems. Each year, we will invite researchers across the MUSC campus to submit a 5-page proposal describing a research plan that specifically addresses novel alcohol treatments or has implications for treatment. A system is in place to review and select pilot projects for funding. Projects supported by this Component will be rigorously monitored for progress, and mentoring will be offered to junior investigators and to those new to the alcohol field. By actively seeking out pilot projects from MUSC researchers across the diverse set of disciplines within the university, we will not only expand our research capabilities, but will provide training and support to investigators who seek to join us in solving the problems associated with alcoholism and excessive drinking.