Core D: Biostatistics Core

生物统计核心旨在加强UNC超级基金研究计划的评估和减少与超级基金高优先化学品相关的人类健康风险。SRP中的五个项目提出了相当大的生物统计学问题和生物信息学挑战，这些问题对项目的成功至关重要。我们的总体目标是(i)提供最先进的生物统计学和生物信息学专业知识，最终用户分析支持和工具开发；（ii）根据需要开发新方法和工具，以实现项目目标；（iii）为学生、博士后和教师营造一个独特的培训环境，为他们应对现代数据集带来的新的复杂挑战做好准备。核心教师和工作人员拥有一系列互补的技能，这将导致统一的数据解释，整合和跨平台分析方法。总的来说，核心与超级基金计划高度相关，因为它将：

The Biostatistics Core is designed to enhance the UNC Superfund Research Program's assessment and reduction of risks to human health associated with Superfund high priority chemicals. The five projects in the SRP present considerable biostatistical issues and bioinformatics challenges that are central to the success of the projects. Our overall aims are to (i) provide state-of-the-art biostatistics and bioinformatics expertise, end-user analytical support, and tool development; (ii) to develop new methods and tools as necessary to address project objectives; (iii) to foster a unique training environment for students, postdoctoral fellows, and faculty to prepare them for the new and complex challenges presented by modern datasets. The Core faculty and staff have a range of complementary skills, which will lead to a unified approaches to data interpretation, integration and cross-platform analysis. Collectively, the Core is highly relevant to the Superfund Program, as it will: ¿ support interdisciplinary (toxicology, genetics, biostatistics, pharmacokinetic modeling) research to elucidate the genetic basis of dose-response and susceptibility; ¿ develop and use state-of-the-art statistical techniques and analysis tools for systems biology approaches; ¿ identify potential biomarkers linked to genetic differences in toxicant metabolism and/or response; and ¿ generate knowledge that is directly applicable to quantitative elucidation of risk. The Core will be involved at the earliest stages of each project, assisting investigators in each step of planning and executing the projects. Each Core faculty member is assigned a role to two projects. A staff statistician with considerable bioinformatics experience will serve as a dedicated analyst, under the guidance of Core faculty members. The Core director will report to the SRP Director, and members, who already collaborate extensively, will meet regularly with the investigators and with each other to plan and exchange ideas.