Graduate Training in Bioinformatics

生物信息学研究生培训

• 批准号: 10628726
• 负责人: Fred A. Wright
• 金额: $ 19.14万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628726
• 关键词: Bioinformatics; Training

ABSTRACT Renewal is requested for a long-running and successful Environmental Health Bioinformatics (EHB) training program at NC State University, with support for 5 predoctoral trainee slots, which will be augmented by generous institutional support. This training program has produced scientists who occupy leadership and key scientific roles conducting Environmental Health Sciences (EHS) research at academic, government, and industry institutions. The structures supporting our EHB program, the Bioinformatics Research Center (BRC) and the Bioinformatics Graduate Program, synergize with institutional strengths in training of predoctoral scientists. The current proposal leverages the momentum in EHS and Data Science at NC State to further enhance EHB training with (i) an expanded leadership structure, (ii) updated training elements and professional development activities, and (iii) a revised training faculty. The administrative organization incorporates new ideas on best practices in research training and enhancing diversity in recruitment, training, and professional opportunities. The revised training faculty align with a new synthesis of EHB, where fundamental research in several disciplinary pillars contributes to advancing EHS: Bioinformatics & Genomics, Quantitative & Computational Methods, and Exposomics & Population Health.

摘要 要求更新长期运行和成功的环境健康生物信息学（EHB）培训 北卡罗来纳州立大学的一项计划，支持5个博士前实习生名额，这将通过慷慨的 机构支持。这项培训计划培养了科学家谁占据领导地位和关键的科学 在学术界、政府和工业界开展环境健康科学（EHS）研究的角色 机构职能体系支持我们的EHB计划，生物信息学研究中心（BRC）和 生物信息学研究生课程，与机构优势协同培养博士前科学家。的 目前的提案利用北卡罗来纳州EHS和数据科学的势头，进一步加强EHB培训 ㈠扩大领导结构，㈡更新培训内容和专业发展活动， 及（iii）经修订的培训学院。行政组织将关于最佳做法的新想法纳入 研究培训和提高招聘，培训和专业机会的多样性。订正 培训教师与EHB的新综合保持一致，其中多个学科支柱的基础研究 有助于推进EHS：生物信息学和基因组学，定量和计算方法，以及 暴露组学与人口健康。

项目成果

Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances (PFAS).

• DOI: 10.1021/acs.est.1c06483
• 发表时间: 2022-03-15
• 期刊: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• 影响因子: 11.4
• 作者: Kirkwood, Kaylie, I;Fleming, Jonathon;Nguyen, Helen;Reif, David M.;Baker, Erin S.;Belcher, Scott M.
• 通讯作者: Belcher, Scott M.

Phylogeny-guided microbiome OTU-specific association test (POST).

• DOI: 10.1186/s40168-022-01266-3
• 发表时间: 2022-06-07
• 期刊: MICROBIOME
• 影响因子: 15.5
• 作者: Huang, Caizhi;Callahan, Benjamin John;Wu, Michael C.;Holloway, Shannon T.;Brochu, Hayden;Lu, Wenbin;Peng, Xinxia;Tzeng, Jung-Ying
• 通讯作者: Tzeng, Jung-Ying

A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.

• DOI: 10.1097/fpc.0b013e3283589c50
• 发表时间: 2012-11
• 期刊: Pharmacogenetics and genomics
• 影响因子: 2.6
• 作者: Brown CC;Havener TM;Medina MW;Auman JT;Mangravite LM;Krauss RM;McLeod HL;Motsinger-Reif AA
• 通讯作者: Motsinger-Reif AA

An eigenvector interlacing property of graphs that arise from trees by Schur complementation of the Laplacian.

由拉普拉斯算子的 Schur 补足产生的图的特征向量交错属性。

• DOI: 10.1016/j.laa.2012.10.005
• 发表时间: 2013
• 期刊: Linear algebra and its applications
• 影响因子: 1.1
• 作者: Griffing,AlexanderR;Lynch,BenjaminR;Stone,EricA
• 通讯作者: Stone,EricA

Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines.

协同化疗药物反应是类淋巴母细胞系的遗传特征。

• DOI: 10.3389/fgene.2019.00829
• 发表时间: 2019
• 期刊: Frontiers in genetics
• 影响因子: 3.7
• 作者: Roell,KyleR;Havener,TammyM;Reif,DavidM;Jack,John;McLeod,HowardL;Wiltshire,Tim;Motsinger-Reif,AlisonA
• 通讯作者: Motsinger-Reif,AlisonA