THE AGES STUDY - THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENUM

NIDCD项目描述：NIDCD项目描述：AGES-Reykjavik研究正在研究遗传易感性和基因/环境相互作用，因为这些因素有助于老年人常见的表型，包括听力损失。NIDCD资助本研究的听力组成部分和平衡问卷将支持听力检查，包括耳镜检查、声导抗（双侧鼓室导抗和同侧声反射）和纯音气导测听，以确定每只耳朵在500、1000、2000、3000、4000、6000和8000 Hz下的听力阈值。2001年至2006年，通过与国家老龄问题研究所达成的机构内协议，NIDCD资助了在冰岛雷克雅未克进行的年龄、基因/环境易感性雷克雅未克研究（AGES雷克雅未克I）中对约5 200名年龄在67至93岁的受试者进行听力检查。D 6在目前的AGES <$雷克雅未克II，NIA和共同赞助的IC（NIDCD，NEI和NINDS）正在资助纵向随访检查。在NIDCD的资助下，将询问有关助听器使用、包括Gallaudet量表在内的听力主观评估、耳鸣（频率和持续时间）、耳部疾病和手术以及与听力有关的其他因素的问题。还将询问有关研究参与者经历过（自年龄I以来）或目前正在经历的特定头晕/平衡和跌倒问题的问题。为了研究广泛的遗传效应，将在现有的AGES数据中确定一级亲属（即，兄弟姐妹和父子组合）。二级亲属或更远的堂兄弟也将被确定。将通过参与广泛的基因组扫描来完成对听力损失遗传学的进一步研究，以确定与定义的表型的关联，包括根据AGES I结果定义的年龄相关听力损失。

NIDCD Project Description: NIDCD Project Description: The AGES-Reykjavik Study is examining genetic susceptibility and gene/environment interaction as these contribute to phenotypes common in old age, including hearing loss. The NIDCD funding of the hearing component and balance questionnaires for this study will support audiometric examinations consisting of otoscopy, acoustic immittance (bilateral tympanometry and ipsilateral acoustic reflexes), and pure-tone, air-conduction audiometry to determine hearing thresholds in each ear at 500, 1000, 2000, 3000, 4000, 6000, and 8000 Hz. Through a prior IntraAgency Agreement with the National Institute on Aging (NIA), NIDCD funded hearing exams on about 5,200 subjects, aged 67 to 93 years in the Age, Gene/Environment Susceptibility Study&#8722;Reykjavik (AGES&#8722;Reykjavik I) in Reykjavik, Iceland from 2001 through 2006. D6 In the present AGES¿Reykjavik II, NIA and co-sponsoring ICs (NIDCD, NEI, and NINDS) are funding longitudinal follow-up exams. With NIDCD funding, questions will be asked about use of hearing aids, subjective evaluation of hearing acuity including the Gallaudet scale, tinnitus (frequency and duration), ear diseases and operations, and other factors related to hearing. Questions will also be asked about specific dizziness/balance and falling problems that study participants have experienced (since AGES I) or are experiencing currently. In order to examine broad genetic effects, first-degree relatives will be identified in the existing AGES data (i.e., siblings and parent-child combinations). Second-degree relatives or more distant cousins will also be identified. Further investigation of the genetics of hearing loss will be accomplished through participation in a broad genome scan for associations with defined phenotypes, including age-related hearing loss defined on the basis of results in AGES I.