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Pilot Projects

Pilot Projects
试点项目
批准号:
8375834
负责人:
DOUGLAS A LAUFFENBURGER
金额:
$12.28万
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-04-17 至 2015-02-28
关键词:
1-Phosphatidylinositol 3-KinaseActinsAddressAffectAntibodiesBehaviorBindingBiological AssayCalibrationCell CommunicationCell physiologyCellsCleaved cellCollaborationsColorCommunitiesComplementComplexComputer SimulationDNA DamageDataDirect CostsDisintegrinsDyesEngineeringEnvironmentEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor Tyrosine Kinase InhibitorEventExtracellular Matrix DegradationFeedbackFilmFluorescenceFluorescence MicroscopyFundingGlycogen (Starch) SynthaseGoalsGrantGrowth FactorGrowth Factor ReceptorsHuman ResourcesIn VitroIndividualLaboratoriesMEKsMatrix MetalloproteinasesMeasurementMeasuresMediatingMetalloproteasesMethodsMicroarray AnalysisModelingNatureNeoplasm MetastasisPathway interactionsPeptide HydrolasesPeptidesPhenotypePhospho-Specific AntibodiesPhosphorylationPilot ProjectsPolymersPreclinical Drug EvaluationProcessProgress ReportsProtease InhibitorProtein MicrochipsProteinsProto-Oncogene Proteins c-aktPublishingPyroxylinReagentRecording of previous eventsRelative (related person)ResearchResearch PersonnelSamplingScienceSignal PathwaySignal TransductionSlideSpecificitySpottingsStimulation of Cell ProliferationSubstrate SpecificitySurfaceSystemTechniquesTimeTissuesTumor Cell InvasionU-0126VariantWestern BlottingWorkantibody conjugatebasecell growth regulationcell motilitychemokinecytokinedesignenzyme activityextracellularfluorophoreinhibitor/antagonistinterestkinase inhibitormalignant breast neoplasmmigrationneoplastic cellnovel strategiespolypeptideprogramsresearch studyresponsesensortechnology developmenttherapeutic targettooltumorwortmannin

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中文摘要
翻译
N4F。试点项目 我们通常的目标是在每个赠款年度为两个试点项目提供催化资金。试点项目有 提供为期两年的资金,每年的直接费用约为6000至9000美元。具体的水平取决于 取得初步成果所需的人员和物资/物资需求的程度和时间 期间允许评估科学和研究人员融入正在进行的项目或 核心。试点项目是由指导委员会从调查人员提交的申请中挑选出来的。 在麻省理工学院(和哈佛)社区,基于提供强大的新方法的潜力, 补充总体计划目标。如果被认为在协作整合方面非常成功,试点 调查员(S)可以成为项目或核心中的常规PI。在之前的授权期内,Pilot 欧内斯特·弗拉恩克尔和迈克·赫曼的指导已经这样做了,进展报告中描述了结果 在研究计划部分中为其对应的项目和核心描述的部分和计划 参与。如果成功续期,计划在赠款第6年进行的两个试点项目如下。
英文摘要
N4F. PILOT PROJECTS We typically aim to provide catalytic funding for two Pilot projects during each grant year. Pilot projects are funded for a period of two years at a level in the range of ~$6oK-9oK direct costs per year. The level depends on the extent of personnel and materials/supplies requirement for gaining preliminary results, and the time period permits assessment of how well the science and investigators integrate into the ongoing Projects or Core. The Pilot projects are selected by the Steering Committee from applications submitted by investigators in the MIT (and Harvard) communities, on the basis of potential for providing powerful new approaches that complement overall program aims. If deemed highly successful in collaborative integration, the Pilot investigator(s) can become regular PIs in the Projects or Core. During the previous grant period, Pilots directed by Ernest Fraenkel and Mike Hemann have done so, with results described in the Progress Report section and plans described in the Research Plans section for their corresponding Project and Core participation. The two Pilots intended for Year 6 of the grant if successfully renewed are presented below.
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