Familial Registries

结直肠癌和胰腺癌的发生涉及环境和遗传因素的相互作用。在这些恶性肿瘤的诊断和治疗中发现的关键是通过对具有良好特征的和可用的患者数据和标本的调查来了解这些因素。CORE 3的目标是为孢子和其他研究人员提供这些材料，以支持结直肠癌和胰腺癌的家族、环境和分子遗传因素的研究。 在这方面，1973年在约翰霍普金斯医院建立了遗传性结直肠癌和息肉综合征患者的登记和临床研究。1982年，肠肿瘤工作组成立，研究结直肠肿瘤的病理生物学和分子遗传学。1991年，形成了核心3。核心数据保存在计算机化的Access数据库和子代数据库中，包括：1)有结直肠癌、早发性结直肠癌和息肉综合征家族聚集史的家庭，以及2)评估结直肠肿瘤患者的家族史和食物频率问卷。1996年扩大了核心数据，将胰腺癌患者的类似数据包括在内。 核心3的具体目标是： 1.收集患有结直肠癌和胰腺肿瘤的高危患者和受影响患者的家族史、病史、病理记录、环境/暴露数据和饮食日期。 2.采集患有结直肠癌和胰腺肿瘤及其相关综合征的高危患者和受影响患者的血液和粪便标本。

The genesis of colorectal and pancreatic cancer involves the interaction of environmental and heritable causes. Key to discoveries in diagnosis and treatment of these malignancies is the understanding of these factors by investigation of well-characterized and available patient data and specimens. The goal of CORE 3 is to provided SPORE and other investigators with these materials to support the research of familial, environmental and molecular genetic factors in both colorectal and pancreatic cancer. With this regard, a registry and clinical study of patients with hereditary colorectal cancer and polyposis syndromes were founded at the Johns Hopkins Hospital in 1973. In 1982, the Bowel Tumor Working Group was formed to study the pathobiology and molecular genetics of colorectal tumors. In 1991 the CORE 3 was formed. The CORE is maintained in computerized Access and Progeny data bases and includes: 1) families with a history of familial aggregation of colorectal cancer, early onset colorectal cancer and polyposis syndromes and 2) family histories and food frequency questionnaires on patients evaluated for colorectal neoplasm. The CORE was expanded in 1996 to include similar data on pancreatic cancer patients. The specific aims of CORE 3 are: 1. To collect family history, medical history, pathological records, environmental/exposure data and dietary date from at risk and affected individuals with colorectal and pancreatic neoplasm and associated syndromes. 2. To procure specimens including blood and stool in at risk and affected individuals with colorectal and pancreatic neoplasm and associated syndromes.