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中文摘要
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描述(由申请人提供):首席研究员/项目主任(最后、第一、中):De Groot, Anne, S.摘要疫苗对全球健康产生了巨大的积极影响,挽救了数百万人的生命,并预防了流行病。由于使用疫苗,小儿麻痹症、麻疹、腮腺炎、破伤风和天花等疾病几乎已被根除。现在,由于全球流行病和生物恐怖主义的威胁,人们越来越认识到疫苗的价值。鉴于传染病在全球蔓延、新型致命病原体的出现以及生物恐怖主义威胁的不断升级,我们建议发起一次疫苗复兴会议。罗德岛大学的免疫学和信息学研究所(I’cubed)将为主要的疫苗研究人员和开发人员主办和组织一次为期三天的会议。该活动将于2011年、2012年和2013年10月在罗德岛普罗维登斯举行。I' cube的使命是通过应用免疫组学——信息学、基因组学和免疫学——的力量来设计更好的疫苗和治疗方法,从而改善人类和动物的健康。I' cube是由医学博士安妮·德·格鲁特(Annie De Groot)用1300万美元的NIH U-19拨款创立的,目的是利用最先进的生物信息学工具,加速传染病和生物防御领域的疫苗发现。该研究所由De Groot博士和Denice Spero博士领导,他们都是药物发现领域经验丰富的研究人员和领导者,并且都非常擅长组织科学活动。2011-2013年疫苗复兴会议的主要目标是提供一个论坛,审查疫苗研究和开发的当前进展,包括加速发现疫苗的新工具和新技术。会议的第二个目标是为全国的疫苗研发界提供交流机会,从而为学术研究人员和疫苗行业领袖之间的合作创造重要机会。将邀请国家和区域疫苗工业和学术领导人就其专业领域的最新疫苗发展发表讲话。这次在I'Cubed举行的疫苗复兴会议将继2004年、2006年和2009年在罗德岛普罗维登斯举行的三次非常成功的疫苗复兴会议之后。第四次会议计划于2010年10月举行。会议的全球呼吁每年吸引了100多名与会者,不仅来自美国,而且来自世界各地。
英文摘要
DESCRIPTION (provided by applicant): Principal Investigator/Program Director (Last, first, middle): De Groot, Anne, S. Abstract Vaccines have had an enormous positive impact on global health saving literally millions of lives and preventing pandemics. Diseases such as polio, measles, mumps, tetanus and smallpox have nearly been eradicated by the use of vaccines. Now with the threat of global pandemics and bioterrorism there is an increased awareness of the value of vaccines. Given the global spread of infectious disease, the emergence of virulent new pathogens and the escalating threat of bio-terrorism, we propose to initiate a Vaccine Renaissance Conference. The Institute of Immunology and Informatics (I'Cubed) at the University of Rhode Island will host and organize a three-day conference for leading vaccine researchers and developers. This event will take place in October 2011, 2012, and 2013 in Providence, RI. The mission of the I'Cubed is to improve human and animal health by applying the power of immunomics --informatics, genomics and immunology -- to the design of better vaccines and therapeutics. The I'Cubed was founded by Annie De Groot, M.D. with a 13M dollar NIH U-19 grant to accelerate vaccine discovery in the areas of infectious diseases and bio-defense using state-of-the-art bioinformatics tools. The Institute is led by Dr. De Groot and Dr. Denice Spero, both highly experienced researchers and leaders in the field of drug discovery and both highly skilled at organizing scientific events. The primary objective of the 2011-2013 Vaccine Renaissance Conference is to provide a forum for the review of current progress in the research and development of vaccines, including new tools and techniques for accelerating vaccine discovery. The second objective of the meeting is to provide a networking opportunity for the vaccine R & D community nationwide, therefore creating important opportunities for collaborations between academic researchers and vaccine industry leaders. National and regional vaccine industry and academic leaders will be invited to speak about recent vaccine developments in their area of expertise. This Vaccine Renaissance Conference at the I'Cubed will follow three highly successful Vaccine Renaissance conferences which took place in 2004, 2006 and 2009 in Providence, Rhode Island. A fourth Conference is planned for October 2010. The global appeal of the Conference attracted more than 100 participants each year not only from the United States, but also from around the world. PUBLIC HEALTH RELEVANCE: Principal Investigator/Program Director (Last, first, middle): De Groot, Anne, S. Narrative Vaccines are the single most important public health tool in saving lives. Vaccines improve the duration and quality of life and have the advantage of preventing diseases before they occur. Many diseases have been eradicated or nearly eradicated by the introduction and use of vaccines. However, there are diseases that have yet to be conquered and remain ripe for vaccine design- HIV, HCV, TB and Malaria to name a few. Given the global spread of infectious disease, the re-emergence of infectious diseases, the persistence of neglected tropical diseases, and the escalating threat of bio-terrorism, it is important for vaccine researchers to gather to discuss their latest research. To that end, the Institute for Immunology and Informatics at the University of Rhode Island proposes a three-day conference for leading vaccine researchers and producers. The conference will emphasize networking between academic researchers and representatives from vaccine-oriented biotechnology companies across the US and worldwide. This conference, "Vaccine Renaissance Conference at the Institute for Immunology and Informatics" will take place October 2011-2013 in Providence, Rhode Island.
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ISPRI-HCP: CHO protein impurity immunogenicity risk prediction for improving biosimilar product development and assessing product interchangeability
  • 批准号:
    10620080
  • 项目类别:
  • 资助金额:
    $200.0万
  • 财政年份:
    2022
  • 负责人:
    Anne Searls DeGroot
  • 依托单位:
Structure-Guided Design of CD4 T cell Memory-Enhanced rHA H7N9 Influenza Vaccine
  • 批准号:
    9362529
  • 项目类别:
  • 资助金额:
    $122.12万
  • 财政年份:
    2017
  • 负责人:
    Anne Searls DeGroot
  • 依托单位:
Structure-Guided Design of CD4 T cell Memory-Enhanced rHA H7N9 Influenza Vaccine
  • 批准号:
    10216952
  • 项目类别:
  • 资助金额:
    $112.35万
  • 财政年份:
    2017
  • 负责人:
    Anne Searls DeGroot
  • 依托单位:
Structure-Guided Design of CD4 T cell Memory-Enhanced rHA H7N9 Influenza Vaccine
  • 批准号:
    9978692
  • 项目类别:
  • 资助金额:
    $113.6万
  • 财政年份:
    2017
  • 负责人:
    Anne Searls DeGroot
  • 依托单位:
国内基金
海外基金
层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
  • 批准号:
    2021JJ40433
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2021
  • 负责人:
    孙磊
  • 依托单位:
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
  • 批准号:
    32001603
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2020
  • 负责人:
    段真珍
  • 依托单位:
AREA国际经济模型的移植.改进和应用
  • 批准号:
    18870435
  • 项目类别:
    面上项目
  • 资助金额:
    2.0万元
  • 批准年份:
    1988
  • 负责人:
    史树中
  • 依托单位: