Macromolecular Diffraction Resource: MacCHESS

MacCHESS，一个用于大分子结晶学的同步辐射研究资源，拥有整体 通过创新的技术研究和开发推动结构生物学前沿的目标 和用户支持。MacCHESS利用国家科学基金会在康奈尔高中的投资 负责维护同步辐射实验室的能量同步加速器源(CHESS)和 运行存储环的基本粒子物理实验室(LEPP)。MacCHESS技术 发展是由核心研究项目和合作研究项目推动的，这些项目涉及广泛的 大分子。除了进行技术研发和核心研究外，MacCHESS还提供 用于大分子结晶学的专门仪器，以及用于用户培训和支持的工作人员。 麦哲思已成为世界上生产高分子材料最多的工厂之一。 结晶学在过去四年中发表了近400篇论文，这是MacCHESS的结果 相关技术研发、核心和协同研究与服务。超过23% 这些论文发表在能见度较高的期刊《科学》、《自然》和《细胞》上。三盘棋 A-1、F-1和F-2站用于大分子结晶学实验。在接下来的五年里 多年来，MacCHESS的技术研发将集中在(1)微晶学，(2)压力冷却及相关 程序，(3)SAXS和包络阶段化，(4)自动化和高通量，以及(5)一个新的站，用于 长波长结晶学。每一项技术研发努力都是由具有挑战性的问题推动的 由研究大分子的原子结构和络合物的合作研究人员提出 目前对医学和生物学的兴趣，包括膜蛋白、信号蛋白复合体、核 酸/蛋白质复合体、蛋白质药物相互作用和病毒。由以下因素导致的技术发展 MacChESS的研究成果可免费提供给科学界，并通过会议传播， 研讨会、出版物、网络分发以及与其他同步加速器来源的合作。

MacCHESS, a synchrotron radiation research resource for macromolecular crystallography, has the overall goal of advancing the frontiers of structural biology through innovative technical research and development and user support. MacCHESS leverages the National Science Foundation investments in the Cornell High Energy Synchrotron Source (CHESS), which maintains the synchrotron radiation laboratory, and the Laboratory for Elementary Particle Physics (LEPP), which operates the storage ring. MacCHESS technical developments are driven by both core and collaborative research projects involving a broad range of macromolecules. In addition to performing technical R&D and core research, MacCHESS provides specialized instrumentation for macromolecular crystallography and a staff for user training and support. MacCHESS has established itself as one of the most productive facilities in the world for macromolecular crystallography with almost 400 papers published during the past four years as a result of MacCHESS related technical research and development, core and collaborative research and service. More than 23 of these papers were published in the high visibility journals, Science, Nature, and Cell. Three CHESS stations, A-1, F-1 and F-2, are used for macromolecular crystallography experiments. During the next five years, MacCHESS technical R&D will focus on (1) microcrystallography, (2) pressure crycooling and related procedures, (3) SAXS and envelope phasing, (4) automation and high-throughput, and (5) a new station for long wavelength crystallography. Each of these technical R&D efforts is driven by the challenging problems presented by collaborating investigators who study the atomic structure of molecules and complexes of great current interest to medicine and biology, including membrane proteins, signaling protein complexes, nucleic acid/protein complexes, protein drug interactions and viruses. Technical developments resulting from MacCHESS research are freely available to the scientific community and disseminated through meetings, workshops, publications, web distributions and collaborations with other synchrotron sources.