Mechanisms of Hematopoiesis in AIDS

描述(由申请人提供)：这个项目将提供新的理解，了解间充质种群如何有助于维持对宿主防御至关重要的组织，即造血系统。提议的目标将使我们了解支持群体或“基质”的动态，该支持群体或“间质”通常被认为仅仅是执行给定器官或组织的工作的实质细胞的支持性架构。这里将使用易处理的造血系统来详细检查间充质-实质的相互作用，并确定是否应该在组织功能障碍和疾病的背景下更广泛地考虑间充质细胞。此外，我们还将了解至少一种高发病率疾病--骨髓发育不良的分子基础。确定类似的途径是否参与艾滋病毒感染的骨髓发育不良可能是可能的，但只有在进行这里详细说明的基础工作的情况下才被认为是可行的。

DESCRIPTION (provided by applicant): This project will provide new understanding of how mesenchymal populations can contribute to the maintenance of a tissue critical for host defense, the hematopoietic system. The proposed aims will inform us about the dynamics of a support population or 'stroma' that is often regarded as a merely supportive architecture for the work of the parenchymal cells that carry out the work of a given organ or tissue. Here will use the tractable system of hematopoiesis to examine the mesenchymal-parenchymal interactions in detail and define whether mesenchymal cells should be considered more broadly in the context of tissue dysfunction and disease. Further, we will learn the molecular basis for at least one variant of a condition of high morbidity, myelodysplasia. Determining whether similar pathways participate in the myelodysplasia of HIV infection may be possible in the out years of the grant, but is considered only feasible if the groundwork detailed here is conducted.