Workshop on the Molecular and Cellular Biology of Plasminogen Activation

描述(由申请人提供)：纤溶系统的激活最终导致血浆酶原纤溶酶原(Pg)蛋白水解性转化为丝氨酸蛋白酶(Pm)(1)。PG激活的主要抑制物纤溶酶原激活物抑制物-1(PAI-1)在主要生理激活物、尿激酶型纤溶酶原激活物(UPA)和组织型纤溶酶原激活物(TPA)水平上调节这一过程，从而形成稳定的丝氨酸/蛋白水解酶复合体。由于纤溶酶原激活领域的快速发展，该领域在过去几年中发生了巨大的变化。几十年来，实验室发现对止血领域新疗法的发展具有独特的重要意义，包括重组组织型纤溶酶原激活剂、溶栓剂和抗血栓药。此外，在此期间，纤溶酶原、纤溶酶及其激活物和抑制物已被证明参与了许多生理学和病理生理学，例如止血、炎症、感染、神经病变，其中许多是通过基因敲除技术和体内模型的发展而发现的。27年前设立纤溶酶原激活的分子和细胞生物学讲习班的目的是鼓励在纤溶酶原生物化学和生物学领域开展工作的不同国家之间的合作。这是一个由初级和高级调查人员介绍情况的讲习班，并鼓励妇女、少数民族、研究生和博士后研究人员出席和参与。这个研讨会的独特之处在于该计划是高度抽象驱动的。这使得会议的重点可以放在新的和未发表的研究上，这将促进与会者之间富有成效的思想交流。讲习班的具体目的是：(1)为青年和高级研究人员提供一个场所，在非正式的环境下介绍和讨论纤溶酶原激活和胞外蛋白分解的生物化学和生理学方面的前沿研究成果。(2)允许传播与这一工作领域有关的新技术。 (3)讨论在各种病理过程中调节这些功能的最新治疗进展。继续举办这一讲习班将有助于确保下一代科学家的发展，他们将成为这一领域的未来。

DESCRIPTION (provided by applicant): Activation of the fibrinolytic system ultimately results in the proteolytic conversion of the plasma zymogen, plasminogen (Pg), to the serine protease plasmin (Pm) (1). The major inhibitor of Pg activation, Plasminogen Activator Inhibitor-1 (PAI-1), regulates this process at the level of the primary physiological activators, urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA), resulting in formation of stable serpin/protease complexes. The field of plasminogen activation has changed dramatically over the past few years due to rapid advances in the field. Over the decades, contributions from laboratory discoveries have been uniquely important for the development of new therapies in the field of hemostasis, including recombinant tissue plasminogen activator, thrombolytics, and anti-thrombolytics. Additionally, during this time, plasminogen, plasmin, and its activators and inhibitors, have been shown to be involved in a number of physiologies and pathophysiologies, e.g., hemostasis, inflammation, infection, neuropathies,-many discovered through the development of gene knock-out technologies and in vivo models. The purpose for establishing the Workshop on Molecular and Cellular Biology of Plasminogen Activation, over 27 years ago, was to encourage collaborations between different countries working in the area of plasminogen biochemistry and biology. It is a Workshop that has a tradition of presentations by junior, as well as senior investigators, and of encouraging the attendance and participation of women, minorities, graduate students, and postdoctoral researchers. This workshop is unique in that the program is highly abstract-driven. This allows for the emphasis of the meeting to be on new and unpublished research, which will foster productive interchange of ideas between attendees of the meeting. The Specific Aims of the workshop are: (1) to provide a venue for young and senior investigators to present and discuss, in an informal setting, cutting-edge research results in the biochemistry and physiology of plasminogen activation and extracellular proteolysis. (2) To allow for the dissemination of new technologies related to this field of work. (3) To discuss the latest therapeutic developments for regulating these functions during various pathologies. Continuation of this workshop will help to assure the development of the next generation of scientists who will become the future of this field.