2012 and 2014 Lysosomes & Endocytosis Gordon Research Conference

描述（由申请人提供）：本申请申请资金部分支持溶酶体和内吞作用的两个连续会议，作为戈登研究会议（GRC）系列的一部分，该会议将于2012年6月17日至22日在新罕布什尔州安多弗的Proctor Academy举行，并于2014年6月再次举行。我们还要求在每次会议之前立即为40-50名研究生和博士后学员提供相关的戈登研究研讨会（GRS）资金。溶酶体和内吞作用GRC具有40多年的传统，是展示内吞途径中膜交通和溶酶体生物学疾病领域前沿研究的关键国际场所。该领域不断发展，最近的进展阐明了内吞途径在新领域的作用，如发育、细胞质分裂、信号传导、先天和适应性免疫、代谢、神经变性和遗传性疾病。通过高质量的正式演讲和严格的海报会议，溶酶体和内吞作用GRC将突出这些领域，并促进新的假设，研究方向和合作的发展。GRC将有大约150名参与者，其中包括至少40名演讲者和8名代表内吞作用和溶酶体生物学研究关键领域的讨论领袖，以及一位对该领域有长期贡献的主题演讲者。2012年的项目将侧重于内吞途径的分子基础，内核体和溶酶体在遗传病中的作用，宿主-病原体相互作用，适应性和先天免疫以及代谢。将从提交的摘要中选出10位发言者，其中一次会议将专门讨论新的方向。此外，两次海报会议-每次跨越两个晚上-将允许所有参与者对这些主题作出贡献。2014年的会议将按照不同的路线组织，但将涵盖许多相同的主题，并将额外关注发育、神经元功能和癌症。溶酶体和内吞作用GRC代表了NIH的一项非常重要的投资，涉及多个研究所的使命。所要求的资金将用于支持受邀演讲者、讨论领袖和初级调查人员的旅行和登记。还要求提供资金支助有关的全球监测系统的被邀请者，其中将向受训者提供背景材料，并鼓励他们互相介绍数据，以培养介绍和建立网络的技能。

DESCRIPTION (provided by applicant): This proposal requests funding for partial support for two sequential meetings on Lysosomes and Endocytosis as part of the Gordon Research Conference (GRC) series to be held in Proctor Academy, Andover, NH from June 17th-22nd 2012 and again in June 2014. We also request funding for an associated Gordon Research Seminar (GRS) for 40-50 graduate student and post-doctoral trainees immediately preceding each Conference. The Lysosomes and Endocytosis GRC has a tradition of over forty years as the key international venue for presentation of cutting edge research in the area of membrane traffic in the endocytic pathway and diseases of lysosome biology. The field continues to evolve, with recent advances elucidating roles for the endocytic pathway in new areas such as development, cytokinesis, signaling, innate and adaptive immunity, metabolism, neurodegeneration and genetic disease. Through high quality formal presentations and rigorous poster sessions, the Lysosomes and Endocytosis GRC will highlight these areas and foster the development of new hypotheses, research directions, and collaborations. The GRC will have approximately 150 participants, including at least 40 speakers and 8 discussion leaders representing critical areas in research in endocytosis and lysosome biology, and a keynote speaker with a long history of contributions to the field. The program for 2012 will focus on the molecular underpinnings of the endocytic pathway, the role of endosomes and lysosomes in genetic disease, host-pathogen interactions, adaptive and innate immunity, and metabolism. Ten speakers will be selected from abstracts submitted and one session will be devoted to discussion of new directions. In addition, two poster sessions - each spanning two evenings - will permit all participants to contribute to these topics. The 2014 conference will be organized along distinct lines but will cover many of the same topics, with additional foci on development, neuronal function and cancer. The Lysosomes and Endocytosis GRC represents a highly significant investment for the NIH with interests touching on the mission of multiple Institutes. The requested funds will be used to support travel and registration for invited speakers, discussion leaders and junior investigators. Funds are also requested to support invitees to the associated GRS, in which trainees will be provided with background material and will be encouraged to present their data to each other to build presentation and networking skills. PUBLIC HEALTH RELEVANCE: The Gordon Research Conference and Gordon Research Seminar on Lysosomes and Endocytosis explore fundamental cellular pathways that underlie normal human physiology, disease, and host defense. These pathways control susceptibility to and defense against infectious disease, cellular digestive pathways that malfunction in genetic, neurodegenerative and nutritional metabolic diseases, growth control pathways related to cancer, and cell interaction pathways required for proper development. The conferences bring together top researchers in the field to discuss their latest and most important research findings, and thereby advance public health by exchanging new ideas, establishing new collaborations, and driving future research areas.