Pacific Center for Emerging Infectious Diseases Research

夏威夷大学马诺阿分校（UH-Manoa）位于太平洋中部最西端的符合IDEA资格的州，距离北美和大洋洲主要岛国约4，000公里，凭借其地理位置接近和与亚太地区机构的密切联系，其战略定位是监测新发现和重新出现的传染病的出现和传播。在最初的五年期间，COBRE的资助使太平洋新发传染病研究中心得以建立，这是一个多学科的英才中心，就区域关注和全球重要的新的、新出现的和重新出现的微生物威胁进行研究和培训。目前正在要求重新提供COBRE资金，以加强和改造COBRE中心，使其成为一个卓越的转化科学中心，为新出现的传染病开发更好的诊断、治疗和干预措施。COBRE活动搬迁到新建的国家资助的20万平方英尺的生物科学大楼的最先进的实验室空间，通过在UH-Manoa创建传染病研究的学术场所，实现了翻天覆地的变化。在本赠款期间，用于非艾滋病毒/艾滋病传染病研究和培训的主流资金约为1 750万美元，远远超过最初的预期。 在这个竞争性的继续重新提交，四个有前途的初级和中级职业教师已被选定为COBRE支持进行假设驱动的研究项目，已被评为优秀到优秀的校外资金的可能性很高。重要的是，已经确定了强有力的领导和专门的导师，合作者和外部顾问，并将加强生物信息学，BSL-3/ABSL-3生物防护以及分子和细胞免疫学的补充技术核心，以确保COBRE研究者在资助期间实现研究独立性。此外，一个机构的承诺，招聘四个额外的热带传染病终身教职的教师和补贴的核心设施将有助于巩固调查人员的临界质量为这个高度优先的研究领域，以及维持这个多学科中心的UH-Manoa和夏威夷州期间和以后的新的赠款期。

Located in the westernmost IDeA-eligible state in the middle of the Pacific Ocean, approximately 4,000 km from North America and the major island nations of Oceania, the University of Hawaii at Manoa (UH-Manoa) is strategically positioned to monitor the emergence and spread of newly recognized and re-emerging infectious diseases, by virtue of its geographic proximity and strong ties to institutions in the Asia- Pacific region. COBRE funding during the initial five-year period has allowed the establishment of the Pacific Center for Emerging infectious Diseases Research, a multidisciplinary center of excellence for research and training on new, emerging and re-emerging microbial threats of regional concern and global importance. Renewed COBRE funding is being requested to strengthen and transform the COBRE Center into a translational science center of excellence for developing improved diagnostics, therapeutics and interventions for emerging infectious diseases. The relocation of COBRE activities into state-of-the-art laboratory space in a newly constructed, State-financed 200,000-square-foot BioSciences Building has exacted a sea change by creating an academic home for infectious diseases research at UH-Manoa. The current grant period has witnessed mainstream funding of approximately $17.5 million for non-HIV/AIDS infectious diseases research and training, far exceeding original expectations. In this competitive continuation resubmission, four promising junior and mid-career faculty have been selected for COBRE support to conduct hypothesis-driven research projects that have been rated as excellent to outstanding with a high likelihood of extramural funding. Importantly, strong leadership and dedicated Mentors, Collaborators and External Advisors have been identified, and complementary technical cores in Bioinformatics, BSL-3/ABSL-3 Biocontainment and Molecular and Cellular Immunology will be enhanced, to ensure that the COBRE Investigators achieve research independence during the grant period. Furthermore, an institutional commitment to recruit four additional tenure-track faculty in tropical infectious diseases and to subsidize core facilities will help to solidify the critical mass of investigators for this high-priority research area, as well as to sustain this multidisciplinary center for UH-Manoa and the State of Hawaii during and beyond the new grant period.