课题基金 / 基金详情

Recombinant Vaccines for Prevention of AIDS and Other Diseases

Recombinant Vaccines for Prevention of AIDS and Other Diseases
用于预防艾滋病和其他疾病的重组疫苗
批准号：
8745295
负责人：
Bernard Moss
金额：
$64.07万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8745295
关键词：
AIDS preventionAdverse effectsAnimalsAntigensCellular ImmunityDNA VaccinesDiseaseHIV vaccineLifePoxviridaeRecombinant ProteinsRecombinant VaccinesResearchTestingVaccinesVaccinia virusViralViral AntigensWorkimprovednonhuman primaterecombinant virus vaccinevaccine candidatevector

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中文摘要
翻译
有许多疾病是没有疫苗的，而其他一些疾病的疫苗并不是最理想的或有显著的副作用。该项目的目标是确定病毒抗原的特征，确定体液和细胞免疫的目标，并利用这些信息开发候选疫苗。正在开发重组病毒活疫苗、DNA疫苗和重组蛋白疫苗。这些疫苗首先在小动物身上进行测试，然后在非人类灵长类动物身上进行测试。目前，我们正在研制针对HIV的痘苗病毒载体疫苗。
英文摘要
There are many diseases for which there are no vaccines and others for which the vaccines are not optimal or have significant side effects. The objectives of this project are to characterize viral antigens, determine targets of humoral and cell mediated immunity, and use this information to develop candidate vaccines. Live recombinant viral vaccines, DNA vaccines and recombinant protein vaccines are being developed. The vaccines are first tested in small animals and then in non-human primates. Presently we are working on vaccinia virus-vectored vaccines for HIV.
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会议论文
Poxvirus DNA Replication
Poxvirus pathogenesis and immunity
Poxvirus Assembly
Recombinant Vaccines for Prevention of AIDS and Other Diseases
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