Perirhinal Cortex and Associative Memory

项目概要： 对于大多数人来说，成功地形成任意联想的记忆的能力是必不可少的。 日常生活的行为。许多研究表明海马体在大脑中起着关键的作用。 在联想记忆中的作用最近的研究表明，嗅周皮层（PRc）也是 参与，但其在联想记忆中的功能作用知之甚少。这 研究计划将使用功能性磁共振成像（FMRI）和新的 行为范式来测试PRc如何有助于联想的三种理论 认可： (1)单位化理论认为，PRc可以支持基于熟悉度的识别， 新的关联，如果成对的项目被编码为一个单一的单位，但 海马体是回忆项目之间的关系所必需的， 单独的单位。新的功能磁共振成像实验提出了测试是否PRc 特别有助于识别被认为是 编码为一个单元。平行的行为研究将测试单位化是否 影响熟悉度指数。 (2)领域理论认为，PRc支持基于熟悉性的识别， 来自同一处理域的项之间的关联，但 海马体需要支持回忆的项目之间的关联， 不同的处理域。新的功能磁共振成像研究提出，以测试是否PRc 支持来自相同处理域的项之间的关联，但不 来自不同域的项目之间的关联。此外，行为研究将 测试域内而非跨域关联是否影响行为 熟悉度指数。 (3)项目和上下文绑定（BIC）理论认为PRc代表项目 信息，PHc表示上下文信息，并且该信息被绑定 海马体的影响。本研究采用功能磁共振成像实验来检验项目回忆是否 信息将与PRc活动相关联，而上下文的回忆 信息将导致PHc活动。 通过对这三种理论的检验，本方案可以为今后的研究提供依据。 发展一个全面的理论MTL功能，可以纳入 编码加工、刺激域和提取加工的影响。几 精神病（例如，精神分裂症）和神经学（例如，阿尔茨海默病和 创伤性脑损伤）疾病与记忆障碍和 内侧颞叶功能障碍这项研究可能会改善 这些疾病的诊断和治疗方法。

Project summary: The ability to successfully form memories for arbitrary associations is essential for most acts of daily living. Numerous studies have shown that the hippocampus plays a critical role in associative memory. Recent work indicates that the perirhinal cortex (PRc) is also involved, but its functional role in associative memory is poorly understood. This research program will use functional magnetic resonance imaging (FMRI) and novel behavioral paradigms to test three theories of how the PRc contributes to associative recognition: (1) Unitization theory asserts that the PRc can support familiarity-based recognition of novel associations if the paired items are encoded as a single unit, but that the hippocampus is required for recollection of relations between items that are encoded as separate units. Novel FMRI experiments are proposed to test whether the PRc specifically contributes to recognition of associations between pairs of items that were encoded as a single unit. Parallel behavioral studies will test whether unitization influences indices of familiarity. (2) Domain theory asserts that the PRc supports familiarity- based recognition for associations between items from the same processing domain, but that the hippocampus is required to support recollection for associations between items from different processing domains. Novel FMRI studies are proposed to test whether the PRc supports associations between items from the same processing domains, but not associations between items from different domains. In addition, behavioral studies will test whether within-domain, but not across-domain associations influence the behavioral indices of familiarity. (3) Binding of items and contexts (BIC) theory asserts that the PRc represents item information, the PHc represents context information, and that this information is bound by the hippocampus. FMRI experiments are proposed to test whether recall of item information will be associated with PRc activity, whereas the recall of contextual information will lead to PHc activity. By testing the three theories, this proposal can provide the foundation for the development of a comprehensive theory of MTL function that can incorporate the influences of encoding processing, stimulus domain, and retrieval processing. Several psychiatric (e.g., schizophrenia) and neurological (e.g., Alzheimer's disease and traumatic brain injury) disorders are associated with memory impairments and with medial temporal lobe dysfunction. The proposed research may lead to improved diagnostic and therapeutic approaches to these disorders.