Medial temporal lobe contributions to cued retrieval of items and contexts.
Medial temporal lobe contributions to cued retrieval of items and contexts.
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DOI：
10.1016/j.neuropsychologia.2013.02.011
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发表时间：
2013-10
期刊：
影响因子：
2.6
通讯作者：
Ranganath C
中科院分区：
文献类型：
--
作者：
Hannula DE;Libby LA;Yonelinas AP;Ranganath C
有几个模型提出，内侧颞叶的不同区域对情景记忆的不同方面有贡献。例如，根据一种观点，嗅周皮层代表特定的项目，海马旁皮层代表关于遇到这些项目的上下文的信息，海马体代表项目-上下文绑定。在这里，我们使用事件相关的功能磁共振成像（fMRI）来测试这个模型的一个特定的预测-即，从上下文线索的项目的成功检索将引发嗅周招募，从项目线索的上下文的成功检索将引发海马旁皮质招募。在任何一种情况下，检索的绑定表示预期引起海马参与。为了测试这些预测，我们让参与者研究了几个项目上下文对（即，分别是物体和场景的图片），然后让他们在扫描检索会话期间尝试从相关联的上下文线索中回忆项目和从相关联的项目线索中回忆上下文。单变量和多变量分析的基础上的结果证实了海马在内容一般关系记忆检索中的作用，以及海马旁皮质在成功检索项目线索的上下文中的作用。然而，我们也发现，在嗅周皮层的活动差异与成功的线索回忆的项目和上下文。这些发现提供了部分支持上述预测，并讨论了几种模型的内侧颞叶功能。
Several models have proposed that different regions of the medial temporal lobes contribute to different aspects of episodic memory. For instance, according to one view, the perirhinal cortex represents specific items, parahippocampal cortex represents information regarding the context in which these items were encountered, and the hippocampus represents item-context bindings. Here, we used event-related functional magnetic resonance imaging (fMRI) to test a specific prediction of this model – namely, that successful retrieval of items from context cues will elicit perirhinal recruitment and that successful retrieval of contexts from item cues will elicit parahippocampal cortex recruitment. Retrieval of the bound representation in either case was expected to elicit hippocampal engagement. To test these predictions, we had participants study several item-context pairs (i.e., pictures of objects and scenes, respectively), and then had them attempt to recall items from associated context cues and contexts from associated item cues during a scanned retrieval session. Results based on both univariate and multivariate analyses confirmed a role for hippocampus in content-general relational memory retrieval, and a role for parahippocampal cortex in successful retrieval of contexts from item cues. However, we also found that activity differences in perirhinal cortex were correlated with successful cued recall for both items and contexts. These findings provide partial support for the above predictions and are discussed with respect to several models of medial temporal lobe function.
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影响因子：
3.5
作者：
Barense, Morgan D.;Henson, Richard N. A.;Lee, Andy C. H.;Graham, Kim S.
通讯作者：
Graham, Kim S.
影响因子：
16.2
作者：
Kriegeskorte N;Mur M;Ruff DA;Kiani R;Bodurka J;Esteky H;Tanaka K;Bandettini PA
通讯作者：
Bandettini PA
影响因子：
64.8
作者：
Epstein, R;Kanwisher, N
通讯作者：
Kanwisher, N
DOI：
10.1080/02724990444000203
发表时间：
2005-07-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
Eacott, MJ
通讯作者：
Eacott, MJ
海马健忘症会损害各种关系记忆。
影响因子：
2.9
作者：
Konkel, Alex;Warren, David E.;Duff, Melissa C.;Tranel, Daniel N.;Cohen, Neal J.
通讯作者：
Cohen, Neal J.