Regulation of Intrinsic Plasticity in Neural Circuits

项目摘要 学习和记忆的能力是一项关键的生存技能，无论你是人还是人 飞。这项提议将利用果蝇丰富的行为和基因来定义和 了解连接睡眠和记忆的神经回路。人类花费了大约三分之一的时间 他们的生活沉睡了。令人惊讶的是，对于为什么我们和其他动物睡觉，没有达成共识，只有 人们一致认为，没有睡眠，我们的大脑就不会以最佳状态运作。一个反复出现的发现， 来自人类、哺乳动物模型系统和果蝇的令人信服的数据是，睡眠是 是形成有效记忆所必需的。我们将研究昼夜节律时钟在 睡眠(特定目标#1)和记忆形成(特定目标#2)都是使用细胞特异性 改变神经元兴奋性的手法。我们将确定并描述以下活动 产生睡眠的时钟下游的细胞(具体目标3)。

Project Summary The ability to learn and remember is a critical survival skill whether you are a human or a fly. This proposal will exploit the behavioral and genetic richness of Drosophila to define and understand neuronal circuits that link sleep and memory. Humans spend roughly one third of their lives asleep. Amazingly, there is no consensus on why we and other animals sleep, only agreement that without sleep our brains do not function optimally. One recurring finding, with convincing data from humans, mammalian model systems, and Drosophila is that sleep is required for effective memory formation. We will investigate the role of the circadian clock in both sleep (Specific Aim #1) and memory formation (Specific Aim #2) using cell specific manipulations that alter neuronal excitability. We will identify and characterize the activity of cells that are downstream of the clock that generate sleep (Specific Aim #3).