BIOSTATISTICS AND BIOINFORMATICS SHARED RESOURCE

上一次拨款申请中正在开发的生物信息学共享资源已被整合到生物统计中，成为生物统计和生物信息学共享资源(BBISR)。BBISR拥有四名(全职)博士级教员、两名(兼职)生物信息学教员和两名硕士级生物统计师，在临床前、临床、实验室、流行病学和分子癌症调查的设计、实施和分析方面与Winship研究人员合作并提供咨询。 BBISR使用一种服务支持模式，该模式利用埃默里大学现有的专业知识和投资来满足Winship成员的需求。具体地说，BBISR通过努力熟练地完成以下研究组成部分来促进研究：设计(满足研究目标的可行性，样本量)，关于关键基础设施的建议，数据分析，准备报告和手稿，审查临床和转化研究委员会的建议，以及根据项目需要开发方法。BBISR的总体目标是确保使用适当的研究 Winship癌症成员研究中的设计和适当的分析方法。BBISR的工作人员在当地融入了整个埃默里大学的Winship研究项目，包括罗林斯公共卫生学院、综合信息学中心，以及亚特兰大临床和转化科学研究所。 与Winship调查人员的合作已导致51份出版物，BBISR工作人员在2010财年提交了38份赠款申请。此共享资源的未来计划包括以下内容： 在早期试验设计中加强现有的生物统计学专门知识，办法是与基因组数据更好地结合，通过招聘更多的教员和工作人员来扩大生物统计学专门知识，培养生物信息学的核心人员，以及建立专门的信息学支持的举措。

The developing Bioinformatics Shared Resource in the previous grant submission has been integrated within biostatistics to become the Biostatistics and Bioinformatics Shared Resource (BBISR). With four (full-time) doctoral level faculty biostatisticians, two (part-time) bioinformatics faculty, and two master-level biostatisticians, BBISR staff members collaborate and consult with Winship investigators in the design, conduct, and analysis of preclinical, clinical, laboratory, epidemiologic and molecular cancer investigations. BBISR uses a service support model that draws upon existing Emory University-wide expertise and investment to meet the needs of Winship members. Specifically, BBISR facilitates research by striving to expertly fulfilling the following study components: design (feasibility in meeting study objectives, sample size), recommendations concerning key infrastructure, data analysis, preparations of reports and manuscripts, review of proposals in the Clinical and Translational Research Committee, and development of methods as needed by project. The overall goal of the BBISR is to ensure the use of proper study design and appropriate analysis methods in Winship cancer members' research. BBISR staff members are integrated both locally, within the Winship research programs throughout Emory University, including the Rollins School of Public Health, the Center for Comprehensive Informatics, and with the Atlanta Clinical and Translational Science Institute. Collaborations with Winship investigators have resulted in 51 publications, and BBISR staff members contributing to 38 grant submissions in CY2010. Future plans for this shared resource include the following: strengthening current biostatistics expertise in early phase trial design by a greater integration with genomic data, expanding biostatistics expertise through additional faculty and staff recruitment, building core personnel in bioinformatics, and initiatives towards building devoted informatics support.