Visible Light Photocatalysis

描述(由申请人提供)：光化学方法是独特的，因为(1)它们能够合成用其他方法无法合成的不寻常的、紧张的分子骨架，以及(2)它们利用光，比传统的化学试剂更清洁、更便宜、更可再生。然而，制药公司很少利用光化学合成，因为需要专门的光化学设备是一个不切实际的障碍，而且几乎没有控制光化学反应立体化学的方法。因此，通过光化学合成产生的分子结构基本上还没有作为可能的候选药物进行检查。这项提议描述了一种创新的新战略，利用现成的可见光光源，如消费性灯泡或周围阳光，而不是专门的光化学反应器，进行光化学反应。研究将分两个阶段进行：1.开发一种光催化系统，能够有效地将可见光能量转化为化学反应，并具有高水平的立体化学控制。2.该体系在各种产生特殊分子结构的新化学反应中的应用。这些方法功能强大、功能强大，且易于在大型工业相关规模上执行。因此，这项提案中描述的研究将对学术化学界和更广泛的药物化学家社区产生重大影响，他们需要新的分子构建方法来发现下一代救命药物。

DESCRIPTION (provided by applicant): Photochemical methods are unique because (1) they enable the synthesis of unusual, strained molecular frameworks that cannot be synthesized by other methods, and (2) they use light, which is cleaner, less expensive, and more renewable than conventional chemical reagents. Nevertheless, pharmaceutical companies rarely take advantage of photochemical synthesis because the need for specialized photochemical equipment is an impractical impediment and because very few methods to control the stereochemistry of photochemical reactions exist. Therefore, the structures of the molecules that are produced by photochemical synthesis have essentially not been examined as possible drug candidates. This Proposal describes an innovative new strategy to perform photochemical reactions using readily available sources of visible light such as a consumer light bulb or ambient sunlight instead of a specialized photochemical reactor. Research will proceed in two phases: 1. Development of a photocatalytic system that is able to efficiently convert visible light energy into chemical reactivity with high levels of stereochemical control. 2. Application of this system to a variety of new chemical reactions that produce unusual molecular structures. These methods are powerful, robust, and simple to perform on large, industrially relevant scales. Thus, the research described in this proposal will significantly impact both the academic chemistry community and the broader community of medicinal chemists who require new methods of molecule construction to discover the next generation of life-saving drugs.