Neural Substrates of Emotion Regulation in Premenstrual Dysphoric Disorder

描述（由申请人提供）：经前烦躁不安（PMDD）是经前综合征的一种严重变体，影响2-5%的育龄妇女，其生活质量下降与重度抑郁症相当（Epperson等人，2012；Halbreich等人，2003；Wittchen等人，2002）。尽管如此，人们对这种疾病的研究还不够充分，对经前不悦症的治疗也因缺乏对其神经生物学基础的了解而受到阻碍。情感性症状，如烦躁/愤怒、抑郁、情绪波动、焦虑，出现在黄体期，表明情绪调节问题可能导致这种障碍，但我们知道没有关于经前不悦症女性情绪调节的研究。我们假设介导情绪调节的神经回路功能障碍是PMDD情感症状的重要因素。这个项目的主要目的是测试这个想法，使用功能性磁共振成像（fMRI），

DESCRIPTION (provided by applicant): Premenstrual dysphoric disorder (PMDD), a severe variant of premenstrual syndrome, affects 2-5% of women in their reproductive years, with decreases in quality of life comparable to those observed in major depressive disorder (Epperson et al., 2012; Halbreich et al., 2003; Wittchen et al., 2002). The disorder is nonetheless understudied, and treatment of PMDD is hindered by a lack of knowledge regarding its neurobiological basis. Affective symptoms, such as irritability/anger, depression, mood swings, anxiety, which appear in the luteal phase, suggest that problems with emotion regulation may contribute to the disorder, but we are aware of no study of emotion regulation in women with PMDD. We hypothesize that dysfunction in the neural circuitry that mediates emotion regulation is an important contributor to the affective symptoms of PMDD. The primary objective of this project is to test this idea, using functional magnetic resonance imaging (fMRI), in women with PMDD and comparison participants without the disorder. Two groups of women (n=18 per group) will undergo fMRI while performing validated tasks that involve presentation of emotionally evocative images, and the intentional and incidental regulation of negative emotional response. Testing will be done during the late luteal phase of the menstrual cycle, when PMDD symptoms occur, and the follicular phase. Success in this project will help clarify the etiology of the symptoms of PMDD, and provide biomarkers for assessing behavioral and pharmacological interventions to ameliorate this disorder.