Olympus VS-120 Virtual Slide Scanning System

描述(由申请人提供)：虚拟载玻片扫描仪和定量软件在允许病理真相定义成像真相方面是绝对必要的。我们通过美国国立卫生研究院的赠款获得资金，以承担这一治疗人类肺癌和前列腺癌的重要任务。拟议的仪器，奥林巴斯VS120载玻片扫描显微镜和VisioMorph Newcast软件，对于完成几个非常重要的NIH资助的研究项目和爱荷华大学的NIH资助的教育资助至关重要。一些直接的应用包括区分肺结节的良恶性，对小鼠、雪貂和猪的肺进行3D重建成像，作为囊性纤维化动物模型的基线，确定胰腺囊性纤维化表型的发展。亨利博士的研究的成功完成将导致在足够早的阶段识别出有致命前列腺癌风险的患者，以便进行有效的治疗。哈蒙德博士要求澄清炎症在慢性疼痛中的作用，从而加强治疗，以提高患者的生活质量 慢性疼痛患者。Dunnwald博士和Murray博士正在分析Irf6蛋白在与伤口愈合相关的免疫细胞中的作用。邦修斯博士将测试基因疗法对亚历山大病的疗效，这是一种对婴儿和儿童具有毁灭性和致命影响的疾病。虚拟幻灯片扫描仪还将支持国家医学图书馆目前资助的一项教育研究和资源提案的显微镜部分，该提案旨在提高临床医学实验室测试订购的效率和成本效益。更新和扩展面向医学、牙科和研究生的虚拟幻灯片箱。虚拟幻灯片箱提高了易用性、学生满意度和学习效率。该数据库还用于评估住院医师的诊断能力。加强医学生和住院医师教育将继续改善无数患者的生活和健康。

DESCRIPTION (provided by applicant): The virtual slide scanner and quantitative software is absolutely essential in allowing pathology truth to define imaging truth. We are funded through NIH grants to undertake this important task for lung and prostate cancer in the human. The proposed instrumentation, the Olympus VS120 slide-scanning microscope with VisioMorph newCAST software is critical for the completion of several very important NIH funded research projects and NIH funded educational grants at the University of Iowa. Some of the immediate applications include distinguishing malignant from benign lung nodules, 3D reconstruction imaging of mouse, ferret and pig lungs as a baseline for animal models in cystic fibrosis animals, defining the development of cystic fibrosis phenotype in the pancreas. The successful completion of Dr. Henry's research will lead to identification of patients at risk for lethal prostte cancer at stages early enough for effective treatment. Dr. Hammond seeks clarification of the role of inflammation in chronic pain leading to enhanced therapies for a higher quality of life for chronic pain patients. Dr. Dunnwald and Dr. Murray are analyzing the role of the protein Irf6 in immune cells associated with wound healing. Dr. Bonthius will test the efficacy of gene therapy against Alexander's disease, a disease with devastating and lethal affects on infants and children. The virtual slide scanner will also support the microscopy component of a current National Library of Medicine funded educational research and resource proposal that is aimed at increasing the efficiency and cost effectiveness of laboratory test ordering in clinical medicin. Updating and expanding the Virtual Slidebox for medical, dental and graduate students. The Virtual Slidebox increases accessibility, student satisfaction and efficiency of learning. This database is also used to assess the diagnostic competency of resident physicians. Enhanced medical student and resident education will continue to improve the lives and health of countless patients.