Hyperpolarizer for 13C MR Metabolic Imaging of Human Subjects and Animal Models

描述（由申请人提供）：本提案是对NCRR“高端仪器资助计划S10”（RFA: PAR-11- 228）的回应，旨在扩大我们对改进仪器的投资，以促进斯坦福大学跨学科项目的生物医学研究，包括理查德·m·卢卡斯成像中心（卢卡斯中心）、斯坦福大学生物医学成像中心（CBIS）和斯坦福大学分子成像项目（MIPS）。今天，转化生物医学研究是至关重要的，随着分子医学和干细胞的快速发展，成像起着至关重要的作用。我们正在申请资金购买通用电气医疗Spinlab动态核偏振器，以扩展我们目前的13C磁共振光谱成像（MRSI）工作。具体来说，我们已经建立了一个非常成功的实验性超偏振13C代谢成像程序，但是，到目前为止，由于我们的临床前偏光器的局限性，只进行了技术研究和小动物研究。提出的新型偏光器将使我们能够在这个项目的基础上，增加进行大型动物和人类研究的能力，这是这项有前途的技术发展的关键一步。与热极化13C核相比，超极化MRS提供了超过10,000倍的信噪比（SNR），形成了MRI和分子成像之间的重要桥梁，新的偏振器将使癌症，心脏病和其他病理的复杂代谢成像研究成为可能，同时确保先进的超极化13C MRS方法在未来几年的持续发展。Spinlab偏振器将位于卢卡斯中心内，该中心作为大学服务中心和ncrr资助的国家研究资源（斯坦福大学先进磁共振技术中心），为校园和更广泛的研究社区提供最先进的磁共振仪器和服务。斯坦福大学放射学系的主要任务是将有前途的新成像模式从实验室环境转化为临床。这个的获得

DESCRIPTION (provided by applicant): This proposal is in response to the NCRR "High End Instrumentation Grant Program S10" (RFA: PAR-11- 228) to expand our investment in improved instrumentation for the advancement of biomedical research in Stanford's interdisciplinary programs including the Richard M. Lucas Center for Imaging (Lucas Center), Center for Biomedical Imaging at Stanford (CBIS), and the Molecular Imaging Program at Stanford (MIPS). Translational biomedical research is of the utmost importance today and, with the rapid advances in molecular medicine and stem cells, imaging plays a vital role. We are requesting funds to purchase a General Electric Healthcare Spinlab" dynamic nuclear polarizer needed to extend our current 13C magnetic resonance spectroscopic imaging (MRSI) efforts. Specifically, we have built a highly successful experimental hyperpolarized 13C metabolic imaging program, but, so far, only technical research and small animal studies have been conducted due to the limitations of our pre-clinical polarizer. The proposed new polarizer will allow us to build upon this program with the additional capability of performing large animal and human studies, a critical step forward in the development of this promising technology. Providing more than a 10,000 fold increase in signal-to-noise ratio (SNR) as compared to thermally polarized 13C nuclei, hyperpolarized MRS forms an important bridge between MRI and molecular imaging, and the new polarizer will enable sophisticated metabolic imaging studies of cancer, heart disease, and other pathologies while ensuring the continued development of advanced hyperpolarized 13C MRS methods for years to come. The Spinlab polarizer will be located within the Lucas Center, which operates as a university Service Center and as an NCRR-funded National Research Resource (Center for Advanced MR Technology at Stanford), supplying state-of-the-art MR instrumentation and services to the campus and broader research community. A primary mission of the Stanford Department of Radiology is the translation of promising new imaging modalities from the laboratory setting to the clinic. The acquisition of this new DNP polarizer is directly aligned with this goal and has great potential to provide new insights into health and disease, ultimately improving patient care.