Training Grant in Teratology

描述(由申请人提供) 这一博士和博士后培训计划的目标是教育科学家，他们将对出生缺陷和产前起源的功能异常的原因和预防提供见解。研究生是从分子和发育生物学(MDB)研究生项目的预科生中挑选出来的，他们对出生缺陷和/或出生前起源的神经行为影响感兴趣。MDB学生选修发育生物学、分子遗传学、细胞生物学、生物化学和研究伦理学等核心课程；畸胎学学生还选修畸胎学、生物统计学和毒理学(推荐)课程。神经畸形学专业的学生还会选修神经科学课程。博士后实习生在研究课程中学习畸形学和伦理学。博士后实习生通过直接向培训教员申请进入培训计划。所有培训教师都在积极运作，所有资助的实验室都有培训研究生和博士后研究员的经验。现在和过去的学员都表现出极高的研究效率，都参加了每年的全国会议，完成后都获得了良好的职位。在过去的10年里，所有受训人员都留在了科学领域；许多人进入了私营部门，从而帮助填补了全国工业领域畸形科医生的短缺。4个博士后和3个博士后职位 都是被要求的。在当前的资助期内，该计划在吸引URM学员方面取得了更多的成功；此外，课程改革加强了分子遗传学、发育生物学和发育疾病方面的培训；新的研究大楼和核心设施已可用，MDB教员已扩大到85人，培训补助金教员增加到15人，其中5人是新获得补助金的人。与5年前相比，现在有更多的培训调查人员调查环境代理人。这一计划填补了一个独特的利基作为唯一的NIEHS畸形学培训拨款，唯一的分子遗传学重点，唯一的主要重点是大脑发展。畸胎学不是一个有自己的学术基础的专业；因此，除了畸胎学之外，分子发育生物学和/或神经生物学的培训为受训者提供了灵活的机会，使他们能够在同等条件下进入畸形学、发育毒理学、神经行为畸胎学、发育生物学或发育神经科学等科学领域。这次更新延续了该项目过去的优势，并增加了新的教师和资源，将畸形学培训转移到更高水平，了解疾病和疾病的产前起源。

DESCRIPTION (provided by applicant) The goal of this doctoral and postdoctoral training program is to educate scientists who will provide insights into the causes and prevention of birth defects and functional abnormalities of prenatal origin. Graduate students are selected from among the Molecular and Developmental Biology (MDB) Graduate Program matriculants with interest in birth defects and/or neurobehavioral effects of prenatal origin. MDB students take core classes in developmental biology, molecular genetics, cell biology, biochemistry, and ethics in research; teratology students additionally take courses in teratology, biostatistics, and toxicology (recommended). Neuroteratology students additionally take courses in neuroscience. Postdoctoral trainees take the teratology and ethics in research courses. Postdoctoral trainees enter the Training Program by applying directly to training faculty members. All training faculty operate active, extramurall funded laboratories and all have experience training graduate students and postdoctoral fellows. Current and past trainees show excellent research productivity, all attend national meetings annually, and all have secured good positions upon completion. All trainees in the last 10 years have remained in science; many have entered the private sector thereby helping to fill the national shortage of teratologists in industry. Four pre-doctoral and three postdoctoral positions are requested. During the current funding period, the program has had additional success attracting URM trainees; in addition, curriculum changes have strengthened training in molecular genetics, developmental biology, and developmental diseases; a new research building and core facilities became available and the MDB faculty has expanded to 85, with the training grant faculty expanding to 15, 5 of whom are new to the grant. More training investigators now investigate environmental agents than 5 years ago. This program fills a unique niche as the only NIEHS training grant in teratology, the only one with a molecular genetics emphasis, and the only one with major focus on brain development. Teratology is not a specialty with its own academic home; accordingly, training in molecular developmental biology and/or neurobiology in addition to teratology provides trainees with flexibility to enter scientifi careers in teratology, developmental toxicology, neurobehavioral teratology, developmental biology, or developmental neuroscience with equal facility. This renewal continues the strengths of the program from the past and adds new faculty and resources to move teratology training to the next level of understanding the prenatal origins of disorders and diseases.