生物分子质谱设施CORE-猫眼课题宝

生物分子质谱设施CORE

批准号：

8448284

负责人：

CLAUDIA S MAIER

金额：

$20.89万

依托单位：

OREGON STATE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/8448284

关键词：

Affect Africa Aging Alzheimer&apos s Disease Amides Amyloid beta-Protein Atmospheric Pressure Binding Bioinformatics Biological Biological Assay Biological Markers Brain Cardiovascular Diseases Cells Charge Chelating Agents Chemicals Chile Chromatography Client Collaborations Complex Computational algorithm Computer software Copper Core Facility Crystallization DNA Data Development Devices Diet Digestion Disease Dissociation Doctor of Philosophy Drops Education Educational process of instructing Electrons Embryo Environmental Exposure Environmental Health Fatty Acids Freezing Frequencies Funding Gases Genome Goals Heart Helium Human Image Individual Inflammation Institution Ionizing radiation Isotope Labeling Isotopes Kidney Diseases Label Laboratories Lasers Lead Learning Ligands Light Lipid Peroxidation Lipids Liquid substance Longevity Magnetism Malignant Neoplasms Maps Mass Spectrum Analysis Measurement Measures Metabolic Diseases Metals Methods Microfluidic Microchips Microfluidics Mission Mitochondria Modeling Motivation Mus Nerve Degeneration Optics Oregon Oxidative Stress Oxygen Parkinson Disease Peptide Fragments Peptides Pesticides Phase Physiologic pulse Pilot Projects Plasma Population Post Translational Modification Analysis Post-Translational Protein Processing Postdoctoral Fellow Predisposition Procedures Process Protein Analysis Protein Biosynthesis Proteins Proteomics Protocols documentation Research Research Personnel Research Project Grants Resolution Resources Robotics Running SHFM1 gene Sampling Sampling Studies Scientist Services Signal Pathway Site Solutions Sorting - Cell Movement Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Staging Stress Structure System Techniques Technology Temperature Testing Therapeutic Intervention Thioctic Acid Time Tissue Sample Tissues Training Variant Vitamin E Water Work X ray diffraction analysis X-Ray Diffraction Xenobiotics Zebrafish Zinc adduct alpha synuclein ascorbate base biocomputing carcinogenesis environmental agent environmental stressor experience fatty acid oxidation graduate student health science research human tissue improved in vivo insight instrument interest ionization link protein macromolecule mass spectrometer member nanomaterials new technology next generation novel novel strategies organic contaminant overexpression oxidation particle prevent professor programs protein complex protein degradation protein expression protein structure prototype quality assurance research study response single molecule small molecule stable isotope three dimensional structure toxicant urinary water sampling

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中文摘要

翻译

这是生物分子质谱设施核心的使命：利用最先进的质谱分析能力，为环境健康相关研究项目提供卓越的支持，开发新技术，最终目标是将这些新技术应用于客户项目，以及作为环境健康科学研究的教育平台。生物分子质谱设施核心（BMSFC）在开发新仪器和电离技术方面积累了30多年的专业知识，用于测量环境样品中的农药和有毒物质。众所周知，持久性生物累积性毒物难以通过质谱法进行分离和裂解。这一挑战推动了我们的许多发展努力。

英文摘要

This is the mission of the Biomolecular Mass Spectrometry Facility Core: ¿ provide exceptional support for environmental health-related research projects using state-of-the-art mass spectral analysis capabilities, ¿ develop new technologies with the ultimate goal of applying these new technologies to client projects, and ¿ serve as an educational platform for environmental health science research. The Biomolecular Mass Spectrometry Facility Core (BMSFC) gained its expertise in developing new instruments and ionization technologies over 30 years of measuring pesticides and toxicants in environmental samples. Persistent bioaccumulative toxicants are notoriously difficult to ionize and fragment by mass spectrometry. This challenge has driven much of our development efforts.

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