Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI)

南非的健康、老龄化和痴呆症:纵向研究 (HAALSI)

基本信息

  • 批准号:
    10627328
  • 负责人:
  • 金额:
    $ 479.21万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-09-15 至 2028-05-31
  • 项目状态:
    未结题

项目摘要

Overall—Abstract Adults in South Africa are surviving to older ages, yet the burden and risk factors of aging-related diseases, particularly dementia and Alzheimer’s disease, remains poorly defined. By 2050, more than 75% of global dementia cases are projected to occur in low- and middle-income countries (LMICs). The proposed renewal of the Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI) Program includes four tightly integrated projects supported by three cores that together will reveal interrelationships among common chronic diseases and other risk factors of cognitive impairment and dementia in South Africa. Each project rests on a common platform of individual surveys, cognitive assessments, biomarker collection, and mortality ascertainment, with additional measures specific to each project. In previous funding cycles (2014-2022), we successfully collected three waves of HAALSI Agincourt data in 5059 men and women ≥40 years of age, achieving response rates of 86-94% among living cohort members. We also collected two waves of data under the Harmonized Cognitive Assessment Protocol (HCAP) at 3-year intervals. For this renewal application, the HAALSI Program will continue following the HAALSI Agincourt cohort (Aim 1), including original enrollees and a refresher sample of 1898, 40- to 49-year-olds, for a total of 13 years of longitudinal data. We will conduct a third HCAP wave on a subsample of the HAALSI Agincourt cohort, with expanded biomarker, neuroimaging, and clinical assessments to understand interactions among cognitive impairment/dementia, HIV infection, and cardiometabolic disorders (CMDs). In Aim 2, we will identify biological, social, and economic predictors of mortality and dementia, and assess disease incidence and changes in physical and cognitive function in the HAALSI Agincourt cohort. In addition, in Aim 3, we will pilot and launch a nationally representative cohort study of 4500 people ≥40 years of age and their partners (approximately 7200 total) using approaches from the HAALSI Agincourt survey; of these, approximately 624 will also undergo the HCAP. The HAALSI National survey will enable us to estimate the prevalence of dementia and other aging-related conditions, and their cross-sectional associations with socioeconomic, behavioral, and health utilization exposures. We will use innovative transportability methods to assess the alignment of diseases in the rural Agincourt community with the national level. In Aim 4, we will evaluate the health impacts of public health and social policies developed to improve healthy aging, specifically those aimed at reducing salt intake, and increasing financial security of older adults, families, and individuals with disabilities. Finally, in Aim 5, we will maximize collaborations with HRS sister studies, H3Africa and DS-I Africa projects, enabling cross-country comparisons and studies at the level of population genetics. Together, the HAALSI Program will produce valuable insights into the burden and drivers of dementia and other aging-related diseases in South Africa, which inform the development of effective policies to ensure healthy aging and wellbeing of aging populations.
Overall-Abstract

项目成果

期刊论文数量(58)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of alcohol use and multimorbidity among adults aged 40 years and above in rural South Africa.
  • DOI:
    10.1038/s41598-023-35018-6
  • 发表时间:
    2023-05-14
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
  • 通讯作者:
Associations between cohort derived dementia and COVID-19 serological diagnosis among older Black adults in rural South Africa.
  • DOI:
    10.3389/fpubh.2023.1304572
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Harriman, Nigel Walsh;Bassil, Darina T.;Farrell, Meagan T.;Du Toit, Jacques;Casas, F. Xavier Gomez-Olive;Tollman, Stephen M.;Berkman, Lisa F.
  • 通讯作者:
    Berkman, Lisa F.
Support in times of need: How depressive symptoms can impact receipt of social support among aging adults in rural South Africa.
  • DOI:
    10.1016/j.ssmph.2020.100666
  • 发表时间:
    2020-12
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jennings EA;Ralston M;Schatz E
  • 通讯作者:
    Schatz E
Hand grip strength and depression among rural older South Africans.
  • DOI:
    10.26555/humanitas.v19i1.10
  • 发表时间:
    2022-02
  • 期刊:
  • 影响因子:
    0
  • 作者:
    K. Peltzer
  • 通讯作者:
    K. Peltzer
Pensions, consumption and health: evidence from rural South Africa.
  • DOI:
    10.1186/s12889-020-09666-6
  • 发表时间:
    2020-10-20
  • 期刊:
  • 影响因子:
    4.5
  • 作者:
    Lloyd-Sherlock P;Agrawal S;Gómez-Olivé FX
  • 通讯作者:
    Gómez-Olivé FX
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LISA F BERKMAN其他文献

LISA F BERKMAN的其他文献

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{{ truncateString('LISA F BERKMAN', 18)}}的其他基金

Cognitive Function, Alzheimer's Disease and Related Disorders in the HAALSI Cohort
HAALSI 队列中的认知功能、阿尔茨海默病和相关疾病
  • 批准号:
    10200613
  • 财政年份:
    2018
  • 资助金额:
    $ 479.21万
  • 项目类别:
Cognitive Function, Alzheimer's Disease and Related Disorders in the HAALSI Cohort
HAALSI 队列中的认知功能、阿尔茨海默病和相关疾病
  • 批准号:
    10465039
  • 财政年份:
    2018
  • 资助金额:
    $ 479.21万
  • 项目类别:
Epidemiology of Alzheimer's Disease and Cognition: Innovative Approaches to Global Harmonization
阿尔茨海默病的流行病学和认知:全球协调的创新方法
  • 批准号:
    9344783
  • 财政年份:
    2016
  • 资助金额:
    $ 479.21万
  • 项目类别:
LEADERSHIP AND ADMINISTRATION
领导和行政
  • 批准号:
    8589022
  • 财政年份:
    2013
  • 资助金额:
    $ 479.21万
  • 项目类别:
Leadership and Administration Core
领导和行政核心
  • 批准号:
    10188351
  • 财政年份:
    2013
  • 资助金额:
    $ 479.21万
  • 项目类别:
SOCIAL AND ECONOMIC PREDICTORS OF PHYSICAL AND COGNITIVE FUNCTION
身体和认知功能的社会和经济预测因素
  • 批准号:
    8589056
  • 财政年份:
    2013
  • 资助金额:
    $ 479.21万
  • 项目类别:
Health and Aging in Africa: Longitudinal Studies of INDEPTH Communities
非洲的健康与老龄化:INDEPTH 社区的纵向研究
  • 批准号:
    8734308
  • 财政年份:
    2013
  • 资助金额:
    $ 479.21万
  • 项目类别:
Core A - Leadership and Administration Core
核心 A - 领导和管理核心
  • 批准号:
    10627329
  • 财政年份:
    2013
  • 资助金额:
    $ 479.21万
  • 项目类别:
Project 1 - Cognitive Function and Dementia
项目 1 - 认知功能和痴呆症
  • 批准号:
    10627332
  • 财政年份:
    2013
  • 资助金额:
    $ 479.21万
  • 项目类别:
Health and Aging in Africa: Longitudinal Studies of INDEPTH Communities
非洲的健康与老龄化:INDEPTH 社区的纵向研究
  • 批准号:
    8551899
  • 财政年份:
    2013
  • 资助金额:
    $ 479.21万
  • 项目类别:

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