Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI)

南非的健康、老龄化和痴呆症：纵向研究 (HAALSI)

• 批准号: 10627328
• 负责人: LISA F BERKMAN
• 金额: $ 479.21万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627328
• 关键词: Adopted; Adult; Africa; Age Years; Aging; Alzheimer' s Disease; Behavioral; Biological; Biological Factors; Biological Markers; Cardiometabolic Disease; Chronic Disease; Clinical assessments; Cognition; Cohort Studies; Collaborations; Collection; Communities; Complex; Country; Data; Data Collection; Dementia; Development; Disabled Persons; Disease; Economic Factors; Economics; Elderly; Ensure; Epidemiology; Family; Funding; Genetic Population Study; HIV; HIV Infections; Health; Health Policy; Health and Retirement Study; Household; Impaired cognition; Incidence; Income; Individual; Interview; Longitudinal Studies; Measures; Methods; Mission; Outcome; Participant; Pattern; Personal Satisfaction; Persons; Physical Function; Policies; Population; Population Dynamics; Population Genetics; Population Research; Prevalence; Protocols documentation; Public Health; Public Policy; Research; Research Project Grants; Rest; Risk Factors; Rural; Rural Community; Sampling; Security; Shapes; Sister; Social Policies; South Africa; Structure; Surveys; System; Woman; aging population; cognitive function; cognitive performance; cognitive testing; cohort; dementia risk; design; experience; follow-up; healthy aging; human old age (65+); improved; innovation; insight; low and middle-income countries; member; men; mortality; neuroimaging; population health; programs; recruit; resilience; response; rural South Africa; salt intake; social; social factors; social health determinants; socioeconomics; virtual

Overall—Abstract Adults in South Africa are surviving to older ages, yet the burden and risk factors of aging-related diseases, particularly dementia and Alzheimer’s disease, remains poorly defined. By 2050, more than 75% of global dementia cases are projected to occur in low- and middle-income countries (LMICs). The proposed renewal of the Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI) Program includes four tightly integrated projects supported by three cores that together will reveal interrelationships among common chronic diseases and other risk factors of cognitive impairment and dementia in South Africa. Each project rests on a common platform of individual surveys, cognitive assessments, biomarker collection, and mortality ascertainment, with additional measures specific to each project. In previous funding cycles (2014-2022), we successfully collected three waves of HAALSI Agincourt data in 5059 men and women ≥40 years of age, achieving response rates of 86-94% among living cohort members. We also collected two waves of data under the Harmonized Cognitive Assessment Protocol (HCAP) at 3-year intervals. For this renewal application, the HAALSI Program will continue following the HAALSI Agincourt cohort (Aim 1), including original enrollees and a refresher sample of 1898, 40- to 49-year-olds, for a total of 13 years of longitudinal data. We will conduct a third HCAP wave on a subsample of the HAALSI Agincourt cohort, with expanded biomarker, neuroimaging, and clinical assessments to understand interactions among cognitive impairment/dementia, HIV infection, and cardiometabolic disorders (CMDs). In Aim 2, we will identify biological, social, and economic predictors of mortality and dementia, and assess disease incidence and changes in physical and cognitive function in the HAALSI Agincourt cohort. In addition, in Aim 3, we will pilot and launch a nationally representative cohort study of 4500 people ≥40 years of age and their partners (approximately 7200 total) using approaches from the HAALSI Agincourt survey; of these, approximately 624 will also undergo the HCAP. The HAALSI National survey will enable us to estimate the prevalence of dementia and other aging-related conditions, and their cross-sectional associations with socioeconomic, behavioral, and health utilization exposures. We will use innovative transportability methods to assess the alignment of diseases in the rural Agincourt community with the national level. In Aim 4, we will evaluate the health impacts of public health and social policies developed to improve healthy aging, specifically those aimed at reducing salt intake, and increasing financial security of older adults, families, and individuals with disabilities. Finally, in Aim 5, we will maximize collaborations with HRS sister studies, H3Africa and DS-I Africa projects, enabling cross-country comparisons and studies at the level of population genetics. Together, the HAALSI Program will produce valuable insights into the burden and drivers of dementia and other aging-related diseases in South Africa, which inform the development of effective policies to ensure healthy aging and wellbeing of aging populations.

总体—摘要 南非成年人的寿命越来越长，但与衰老相关的疾病的负担和危险因素， 特别是痴呆症和阿尔茨海默病，仍然没有明确的定义。到 2050 年，全球 75% 以上 痴呆症病例预计将发生在低收入和中等收入国家（LMIC）。拟议的续订 南非的健康、老龄化和痴呆症：纵向研究 (HAALSI) 计划包括四个项目 由三个核心支持的紧密集成的项目将揭示共同点之间的相互关系 南非的慢性疾病以及认知障碍和痴呆症的其他危险因素。每个项目 依赖于个人调查、认知评估、生物标志物收集和死亡率的通用平台 确定，并针对每个项目采取额外措施。在之前的融资周期（2014-2022）中，我们 成功收集了 5059 名 40 岁以上男性和女性的三波 HAALSI Agincourt 数据， 在世队列成员中实现 86-94% 的响应率。我们还收集了两波数据 每 3 年进行一次协调认知评估协议 (HCAP)。对于本次续展申请， HAALSI 计划将继续遵循 HAALSI Agincourt 队列（目标 1），包括最初的参与者和 1898 年 40 至 49 岁人群的复习样本，总共 13 年的纵向数据。我们将进行一次 第三次 HCAP 波针对 HAALSI Agincourt 队列的子样本，扩展了生物标志物、神经影像学、 和临床评估，以了解认知障碍/痴呆、艾滋病毒感染和 心脏代谢紊乱（CMD）。在目标 2 中，我们将确定生物、社会和经济预测因素 死亡率和痴呆症，并评估疾病发病率以及身体和认知功能的变化 HAALSI 阿金库尔队列。此外，在目标3中，我们将试点并启动一项具有全国代表性的队列研究 使用以下方法对 4500 名 40 岁以上的人及其伴侣（总共约 7200 人）进行了调查： HAALSI 阿金库尔调查；其中，大约 624 人还将接受 HCAP。 HAALSI 国家 调查将使我们能够估计痴呆症和其他与衰老有关的疾病的患病率及其影响 与社会经济、行为和健康利用暴露的横截面关联。我们将使用 创新的可运输性方法来评估阿金库尔农村社区的疾病与 国家层面。在目标 4 中，我们将评估公共卫生和社会政策对健康的影响，以实现 改善健康老龄化，特别是那些旨在减少盐摄入量和提高经济安全的目标 老年人、家庭和残疾人。最后，在目标 5 中，我们将最大限度地与 HRS 姊妹研究、H3Africa 和 DS-I Africa 项目，使跨国比较和研究成为可能 群体遗传学水平。 HAALSI 计划将共同对负担和负担产生宝贵的见解。 南非痴呆症和其他与衰老相关的疾病的驱动因素，这为开发有效的治疗方法提供了信息 确保健康老龄化和老龄人口福祉的政策。

项目成果

Support in times of need: How depressive symptoms can impact receipt of social support among aging adults in rural South Africa.

• DOI: 10.1016/j.ssmph.2020.100666
• 发表时间: 2020-12
• 期刊: SSM - population health
• 作者: Jennings EA;Ralston M;Schatz E
• 通讯作者: Schatz E

Associations between cohort derived dementia and COVID-19 serological diagnosis among older Black adults in rural South Africa.

• DOI: 10.3389/fpubh.2023.1304572
• 发表时间: 2023
• 期刊: FRONTIERS IN PUBLIC HEALTH
• 影响因子: 5.2
• 作者: Harriman, Nigel Walsh;Bassil, Darina T.;Farrell, Meagan T.;Du Toit, Jacques;Casas, F. Xavier Gomez-Olive;Tollman, Stephen M.;Berkman, Lisa F.
• 通讯作者: Berkman, Lisa F.

Association of alcohol use and multimorbidity among adults aged 40 years and above in rural South Africa.

• DOI: 10.1038/s41598-023-35018-6
• 发表时间: 2023-05-14
• 期刊: Scientific reports
• 影响因子: 4.6

Hand grip strength and depression among rural older South Africans.

• DOI: 10.26555/humanitas.v19i1.10
• 发表时间: 2022-02
• 期刊: Humanitas
• 作者: K. Peltzer

Pensions, consumption and health: evidence from rural South Africa.

• DOI: 10.1186/s12889-020-09666-6
• 发表时间: 2020-10-20
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Lloyd-Sherlock P;Agrawal S;Gómez-Olivé FX
• 通讯作者: Gómez-Olivé FX