Biostatistics and Bioinformatics

生物统计学和生物信息学核心设施为所有GI癌症SPORE研究人员提供统计和计算支持。核心将支持研究设计、数据库开发和质量控制以及数据分析和解释等各个方面的咨询和合作。参与生物统计学和生物信息学核心的统计学家和生物信息学科学家因其在临床试验，实验室实验，遗传学和基因组学研究，计算生物学和流行病学研究方面的广泛专业知识和经验而被选中。Dianne Finkelstein博士和Hui Zheng博士在综合癌症中心和肿瘤协作组中担任统计学家，拥有丰富的经验。John Quackenbush博士是Dana-Farber癌症研究所（DFCI）癌症计算生物学中心的负责人，在基因组学和计算生物学方面拥有丰富的经验。Barbara Weir博士和Nicholas Sttransky博士是计算生物学家，他们在开发和部署分析和整合基因组数据集的方法方面拥有深厚的专业知识。这些人共同隶属于马萨诸塞州总医院（MGH）、DFCI、哈佛医学院（HMS）、哈佛公共卫生学院（HSPH）以及哈佛和麻省理工学院的布罗德研究所。然而，他们的SPORE合作将基于专业领域和需求，并将涉及来自几个附属机构的调查人员。生物统计学和生物信息学核心成员定期参加规划会议，讨论SPORE项目的科学目标和研究方法。该核心设施的具体目标是：1：为GI癌症SPORE计划提供随时可用的统计和生物信息学专业知识和计算咨询; 2：为实验室实验，流行病学研究和临床试验的规划，分析和报告提供生物统计/生物信息学专业知识; 3：建议和支持SPORE研究人员及其数据收集者（技术人员，护士，数据管理员等）。在数据形式设计、数据收集、记录提取、计算机化、数据库设计和管理以及数据质量控制等领域提供支持; 4：为综合计算模型的开发提供支持，以促进复杂基因组数据集的分析和解释; 5：提供满足GI癌症SPORE研究者的数据管理和分析需求所需的科学计算专业知识。

The Biostatistics and Bioinformatics Core facility provides the statistical and computational support for all GI cancer SPORE investigators. The Core will support consultation and collaboration on all aspects of study design, database development and quality control, and analysis and interpretation of data. The statisticians and bioinformatics scientists participating in the Biostatistics and Bioinformatics Core have been chosen for their broad range of expertise and experience in clinical trials, laboratory experiments, genetics and genomics research, computational biology and epidemiology studies. Dr. Dianne Finkelstein and Dr. Hui Zheng have extensive experience as statisticians within the comprehensive cancer center and cooperative oncology group settings. Dr. John Quackenbush directs the Center for Cancer Computational Biology at the Dana-Farber Cancer Institute (DFCI) and has extensive experience in genomics and computational biology. Dr. Barbara Weir and Nicholas Stransky are computational biologists who have deep expertise in the development and deployment of methods to analyze and integrate genomic datasets. Collectively these individuals have affiliations at Massachusetts General Hospital (MGH), DFCI, Harvard Medical School (HMS), Harvard School of Public Health (HSPH) and the Broad Institute of Harvard and MIT. However, their SPORE collaborations will be based on areas of expertise and need and will involve investigators from several of the affiliate institutions. The Biostatistics and Bioinformatics Core members have participated regularly in the planning meetings where the scientific goals and research methods of the SPORE projects were discussed. The specific aims of this core facility are to; 1: Provide ready access to statistical and bioinformatics expertise and computing consultation to the GI cancer SPORE program; 2: Provide biostatistical/bioinformatics expertise for the planning, analysis and reporting of laboratory experiments, epidemiology studies and clinical trials; 3: Advise and support SPORE investigators and their data collectors (technicians, nurses, data managers, etc.) in the areas of data form design, data collection, record abstraction, computerization, database designing and management, and data quality control; 4: Provide support for the development of integrative computational models to facilitate the analysis and interpretation of complex genomic datasets; 5: Provide the scientific computing expertise required to meet the data management and analytical needs of GI cancer SPORE investigators.