Post Graduate Training in Pediatric Oncology

描述（由申请人提供）：科罗拉多大学丹佛分校（UCD）和儿童医院（TCH）的儿科血液学/肿瘤学奖学金项目拥有超过35年的杰出历史。在过去的5年中，随着新建成的安舒茨医学校园（AMC）的过渡，培训计划受益匪浅。儿科肿瘤实验室在2004-2005学年搬迁到扩大，国家的最先进的研究空间在AMC。2007年9月，TCH也搬迁到AMC，成为一个144万平方英尺的新医院，包括294张床位，为落基山脉地区七个州的患者提供服务。因此，这是该项目历史上第一次，儿科肿瘤学学员被安置在一个医学校园，包括TCH，科罗拉多大学医院，UCD医学院和科罗拉多生物科学园区。在向新校区过渡的过程中，儿科肿瘤学奖学金项目和教员的规模也有了显著的增长，现在由25名临床教员组成，每年有4名新研究员进入为期三年的奖学金项目。与此同时，T32研究培训学院已扩大到30名成员，增加了给研究员进行儿科肿瘤学实验室、转化或临床研究的机会。T32培训学院代表了广泛的科学学科，包括细胞周期控制和信号传导，转录调控和剪接，病毒学和免疫学。此外，还增加了具有临床研究和转化肿瘤学专门知识的培训教员，包括确定用于药物开发的新型生物靶点。培训计划最初是在2000年由T32拨款资助的，目前提交的是该支持的第二次竞争性续期。由于临床经验的广度、儿童医院卓越的临床声誉和新的研究机会，自1993年以来，奖学金候选人的质量和对学术生涯的奉献精神不断提高。事实上，在过去5年的奖学金项目中，15名毕业生中有13名现在在学术院系工作，2007年以来的所有毕业生都有学术院系职位。研究金的最短期限为三年。第一年几乎全部用于临床培训，而第2年和第3年至少80%的时间用于研究。目前，该项目共有12名研究员，他们都已经完成了儿科住院医师实习期，其中8名在他们的第一个临床研究年度之后正在接受研究培训。本提案旨在为那些选择在奖学金的第二年和随后几年从事儿科肿瘤相关研究的医学博士研究员提供资金，并选择致力于儿科癌症研究的博士和博士后研究员。历史和最近的发展都标志着这个培训项目是全国最好的之一。

DESCRIPTION (provided by applicant): The Pediatric Hematology/Oncology Fellowship Program at the University of Colorado Denver (UCD) and The Children's Hospital (TCH) has a distinguished history spanning over 35 years. Over the last 5 years, the Training Program has benefited significantly with the transition to the newly built Anschutz Medical Campus (AMC). The Pediatric Oncology laboratories relocated in the 2004-2005 academic year into expanded, state-of-the art research space on the AMC. In September 2007, TCH also relocated onto the AMC into a new 1.44 million square feet hospital that includes 294 beds and serves patients from seven states in the Rocky Mountain region. Thus, for the first time in the history of the program, Pediatric Oncology trainees are located on one medical campus which includes TCH, University of Colorado Hospital, UCD School of Medicine, and the Colorado Biosciences Park. The Pediatric Oncology Fellowship Program and faculty also grew significantly in size during this transition to the new campus and now consist of 25 Clinical Faculty with 4 new fellows entering the 3-year Fellowship Program annually. In parallel, the T32 Research Training Faculty has been expanded to 30 members, increasing the opportunities given to fellows to perform laboratory-based, translational or clinical research in pediatric oncology. The T32 Training Faculty represent a broad range of scientific disciplines including cell cycle control and signaling, transcriptional regulation and splicing, virology, and immunology. Training Faculty with specific expertise in clinical research and translational oncology, including identification of novel biologic targets for drug development, have also been added. The Training Program was initially funded in 2000 with this T32 grant, and the current submission is the second competitive renewal of this support. Because of the breadth of the clinical experience, the outstanding clinical reputation of the Children's Hospital, and the new research opportunities available, fellowship candidates since 1993 have consistently increased in quality and dedication to an academic career. Indeed, 13 of 15 graduates in the last 5 years of the Fellowship Program are now in academic faculty, and all graduates since 2007 have academic faculty positions. The minimal fellowship duration is three years. The first year is devoted almost exclusively to clinical training, while at least 80% of time during years 2 and 3 is devoted to research. Currently there are 12 fellows in the Program, all of whom have previously completed their Pediatric residencies, with 8 currently in research training beyond their first clinical fellowship year. This proposal seeks funding for those MD fellows who elect to pursue research related to Pediatric Oncology in the second and subsequent years of the fellowship, and select PhD post-doctoral fellows committed to a career in pediatric cancer research. Both history and recent developments thus mark this training program as one of the best in the nation.