Hearing Loss and Aging

简介（由申请人提供）：Frank Lin博士是约翰霍普金斯医学院耳鼻喉头颈外科的初级教员，他的临床实践致力于听力损失和耳科。他之前在约翰霍普金斯大学彭博公共卫生学院完成了临床研究博士学位，在那里他将世界卫生组织开发的功能概念模型应用于儿科人工耳蜗植入（CI）的评估。在导师职业发展奖的支持下，林博士试图更好地了解听力损失对老年人健康和功能的影响，以及CI等治疗方式在减轻这些影响方面的作用。林博士将通过老年病学和生物统计学的课程来提高他的研究知识和技能，接受由经验丰富的临床研究人员组成的跨学科团队的指导，并沉浸在国家老龄化研究所纵向研究部，约翰霍普金斯大学老龄化与健康中心，约翰霍普金斯大学Dana预防眼科中心和约翰霍普金斯大学听力中心的跨学科研究和临床环境中。该CDA将为林博士提供他成为听力损失和临床研究的独立研究者和未来领导者所需的资源。基于他之前利用健康结果概念模型的研究经验，林博士开发了一个新的框架来理解和研究听力损失对老年人的影响，该框架借鉴了认知心理学、社会流行病学、老年学和听力科学等领域。在目标1中，他将使用四个已建立的前瞻性数据集来研究听力损失对认知、社会孤立、痴呆、功能衰退、医疗支出和死亡率等领域的影响。本研究将为研究听力损失对衰老的影响奠定基础。在目标2中，他将前瞻性地招募在听力中心接受CI的成年患者，研究CI对健康和功能领域的影响。这项工作将为助听器和人工耳蜗的植入以及未来听力损失干预的临床试验提供策略。

DESCRIPTION (provided by applicant): Dr. Frank Lin is a junior faculty member in the Department of Otolaryngology-Head & Neck Surgery at the Johns Hopkins School of Medicine where his clinical practice is dedicated to hearing loss and otology. He previously completed a Ph.D in Clinical Investigation at the Johns Hopkins Bloomberg School of Public Health where he applied conceptual models of functioning developed by the World Health Organization to the assessment of pediatric cochlear implantation (CI). With the support of this Mentored Career Development Award, Dr. Lin seeks to better understand the impact of hearing loss on the health and functioning of older adults and the role of therapeutic modalities such as CI in mitigating these effects. Dr. Lin will enhance his research knowledge and skills with coursework in geriatrics and biostatistics, receive directed mentorship by an interdisciplinary team of experienced clinical researchers, and be immersed in the interdisciplinary research and clinical environments of the Longitudinal Studies Section of the National Institute on Aging, the Johns Hopkins Center on Aging and Health, the Johns Hopkins Dana Center for Preventive Ophthalmology, and the Johns Hopkins Listening Center. This CDA will provide Dr. Lin with the resources that he needs to become an independent investigator and future leader in hearing loss and clinical research. Building on his prior research experience in utilizing conceptual models of health outcomes, Dr. Lin has developed a novel framework to understand and study the impact of hearing loss on older adults that draws on the fields of cognitive psychology, social epidemiology, gerontology, and the hearing sciences. In Aim 1, he will use four established prospective datasets to study the effects of hearing loss on domains of cognition, social isolation, dementia, functional decline, health care expenditures, and mortality. This work will establish the basis for the impact of hearing loss in aging. In Aim 2, he will prospectively recruit adult patients undergoing CI at the Listening Center into a study examining the effects of CI on domains of health and functioning. This work will inform strategies for hearing aid and cochlear implant delivery and future clinical trials of hearing loss interventions.