Pathogenesis of Infectious Diseases Training Program

描述(申请人提供)：该计划的目标是培训生物医学研究人员，重点是内科科学家，在基础和翻译生物医学研究的重点是传染病的发病机制。培训计划将利用威尔康奈尔医学院、洛克菲勒大学和亚伦·戴蒙德艾滋病研究中心的资源。该项目的教职员工都是资助科学家，致力于研究和培训。六位新的潜在导师已经被包括在内，他们都得到了NIH独立的研究支持。培训教师在通过NIH Fogarty计划成功合作研究和培训国际生物医学科学家方面有着悠久的历史，他们已经将这些经验应用到美国内科科学家的培训中。教职员工一致认为，内科科学家确实是濒危物种，并致力于通过与博士后实习生建立长期指导关系来解决这一问题。研究培训的广泛领域包括：病毒学、免疫学和与具有全球重要性的传染病有关的转化研究。学员有机会参加K30临床研究硕士课程，或酌情参加独立研究生水平的免疫学和分子生物学课程。在本供资期间(1999-2008年)，任命了23名学员，17名学员完成了培训。其中10人获得了NIH“K”奖，1人获得了研究补充，2人获得了“K”助学金。资助奖项的主题领域是KSHV-HHV8、艾滋病毒发病机制、艾滋病毒基因耐药性、丙型肝炎病毒-艾滋病毒共同感染、艾滋病毒-结核病共同感染、多药耐药细菌、-艾滋病毒疫苗开发、利什曼病发病机制和结核分枝杆菌-无相互作用。两名前受训人员已经获得了NIH“R”奖，两人在主要的公共卫生职位(CDC，NYC)。有4名少数族裔受训人员(3名非裔美国人，1名西班牙裔)和9名女性受训人员。该计划将继续招聘已完成临床培训(医学、儿科)并正在寻求学术研究职业的医生。这笔培训补助金将为医生提供从临床培训过渡到实验室的机会。研究性培训为期2-3年。 相关性(参见说明)：该培训计划将为内科科学家提供所需的技能和指导，以便在美国和世界范围内成功地从事对公共卫生具有重要意义的传染病的研究。具体地说，培训将侧重于结核病、疟疾、艾滋病、丙型肝炎病毒和潜在的生物恐怖主义病原体。

DESCRIPTION (provided by applicant): The objective of this program is to train biomedical researchers, with an emphasis on physician-scientists, in basic and translational biomedical research focusing on the pathogenesis of infectious diseases. The training program will utilize the resources of Weill Cornell Medical College, the Rockefeller University, and the Aaron Diamond AIDS Research Center. The program's faculty are funded scientists, committed to research and training. Six new potential mentors have been included, all with independent NIH research support. The training faculty has a long history of successful collaboration in research and training of international biomedical scientists through NIH Fogarty programs, and they have applied that experience to the training of US physician-scientists. The faculty members share the view that the physician-scientist is truly an endangered species and are committed to address this issue by establishing long-term mentoring relationships with postdoctoral trainees. The broad areas of research training are: virology, immunology, and translational research related to infectious diseases of global importance. Trainees have the opportunity to enroll in the K30 Masters in Clinical Investigation program or take independent graduate level immunology and molecular biology courses as appropriate. During the current funding period (1999-2008), 23 trainees have been appointed and 17 have completed training. Ten have received NIH "K" awards, one a research supplement, and two have "K" grants in preparation. The subject areas for the funded awards are KSHV-HHV8, HIV pathogenesis, HIV genotypic resistance, HCV-HIV coinfection, HIV-TB coinfection, multidrug resistance bacteria,-HIV vaccine development, leishmania pathogenesis and M. tuberculosis-NO interaction. Two former trainees have already received NIH "R" awards and two are in major public health positions (CDC, NYC). There have been four minority trainees (3 African-American, 1 Hispanic) and nine female trainees. The program will continue to recruit physicians who have completed their clinical training (medicine, pediatrics) and are seeking academic investigative careers. This training grant will provide physicians with an opportunity to make the transition from their clinical training to the laboratory. The research training will be for 2-3 years. RELEVANCE (See instructions): This training program will provide physician-scientists with the skills and mentoring needed to embark on successful careers conducting research in infectious diseases of public health importance both in the United States and worldwide. Specifically, the training will focus on tuberculosis, malaria, AIDS, hepatitis C virus, and potential agents of bioterrorism.