Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy

描述(由申请人提供)：本项目名为“儿科抗菌药物治疗的发展和转译药理学”，是根据RFA-HD-10-026：儿科发展药理学专业研究中心计划(U54)的申请提交的。加州大学圣地亚哥分校拟议项目的总体主题是将发育生理学、药理学和传染病领域的非临床和临床专家聚集在一起，并进行转化性研究，以推动儿科发育药理学领域的发展。该方案由3个主要项目、2个试点项目和4个核心项目组成。这三个主要项目分别是“婴幼儿乐果剂量优化”、“药物与内源性抗生素之间的药物相互作用”和“发展方面的问题”。 氨基青霉素肾清除量“。每个项目都利用行政核心(A)、药理计量核心(B)、定量药理分析核心(C)和培训和推广核心(D)。与这些项目和核心合作，将描述抗菌治疗处置和潜在毒性方面的发展变化。该计划将利用加州大学迭戈分校基础科学实验室的发现，并将这些研究扩展到非临床和临床领域。这些核心将开发适合整个儿科年龄范围的药理分析，并利用创新的建模和模拟技术来优化这些项目产生的知识，并帮助在临床和非临床结果之间建立联系。这些项目和核心活动将为未来的儿科药师提供丰富的培训环境。而当 这一RPDP计划的重点是解决与抗菌治疗相关的发育药理学问题，了解大鼠和人类燕麦转运体成熟的决定因素对其他类别的药物进行肾脏排泄具有广泛的意义。

DESCRIPTION (provided by applicant): This program, entitled "Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy", is submitted as an application responsive to RFA-HD-10-026: Specialized Center in Research in Pediatric Developmental Pharmacology (RPDP) Program (U54). The overall theme of the proposed program at the UC San Diego is to bring together non-clinical and clinical experts in the fields of developmental physiology, pharmacology, and infectious diseases and conduct translational research to advance the field of pediatric developmental pharmacology. This program is comprised of 3 Main Projects; 2 Pilot Projects and 4 Cores. The three main projects are "Colistimethate Dose Optimization in Infants and Children", "Drug-Drug Interactions between Pharmaceutical and Endogenous Antibiotics" and "Developmental Aspects of Aminopenicillin Renal Clearance". Each project utilizes the Administrative Core (A), the Pharmacometrics Core (B), the Quantitative Pharmacology Assay Core (C) and the Training and Outreach Core (D). Working together these projects and cores will characterize developmental changes in the disposition and potential toxicity of antimicrobial therapy. The program will capitalize on the discoveries made in basic science laboratories at UC Diego and extend these investigations in both non-clinical and clinical domains. The Cores will develop pharmacologic assays that are appropriate across the pediatric age continuum and utilize innovative modeling and simulation techniques to optimize the knowledge generated from these projects and help establish links between clinical and non-clinical findings. These projects and core activities will provide a rich training environment for future pediatric pharmacologist. While this RPDP program is focused to address developmental pharmacologic issues relating to antimicrobial therapy, understanding the determinants of Oat transporter maturation in both rat and humans has broad Implications for other classes of drugs undergoing renal excretion.