Clinical Pharmacoepidemiology Training Grant

描述（由申请人提供）：宾夕法尼亚大学医学院临床流行病学和生物统计学中心（CCEB）提交此续期申请，以继续和扩大临床药物流行病学（即药物在人群中的使用和效果）方面的创新和成功的博士后培训计划。宾大提倡鼓励基础和临床研究的学术环境，并将其视为有吸引力的职业道路。该培训项目吸引了全国其他机构的临床药物流行病学学员。预计该培训计划的许多毕业生将被安置在全国其他机构，从而产生最大的影响。两到三年的培训课程包括临床流行病学、研究方法学、生物统计学、药物流行病学、药代动力学；选修药理学、药学实践或与学员兴趣和经验相关的其他领域的课程；广泛的独立阅读；参加行政协调会的研究研讨会；临床药理学的临床经验；完成一项受指导的临床药物流行病学独立研究项目。该计划旨在：1)培训临床医生成为严谨和独立的学术研究者，能够使用流行病学中可用的一系列方法来解决与病因，预后，预防和早期检测，治疗，临床经济学，技术评估，医疗决策和患者护理质量相关的临床药物流行病学研究问题；2)了解临床药理学的基本原理；3)为导师提供临床药物流行病学方面的强化、有监督的研究经验；4)在临床药物流行病学方面与教师导师进行密切的研究指导；5)加强传统流行病学与临床药理学的联系。随着该培训计划的扩大，每年将颁发5个奖学金名额。学员将获得临床流行病学硕士学位（MSCE）。该计划的优势在于：1)有大量非常强大的候选人寻求药物流行病学培训；2) CCEB长期以来成功的研究培训项目，包括国际知名的临床药物流行病学项目和比较有效性研究（NIH感兴趣的新领域）的重叠培训；3)为学员提供全面的课程设置和研究项目；4)项目主任和教师的成功培训记录。此外，CCEB教师的可用性，他们提供广泛学科的专业知识；对研究项目和培训有用的众多大型数据库；可用于临床研究的广泛的专业分析能力（例如，临床试验、病例对照、队列研究等）；院系对合作研究和培训的承诺，为这个项目提供了一个理想的环境。

DESCRIPTION (provided by applicant): The Center for Clinical Epidemiology and Biostatistics (CCEB) of the University of Pennsylvania (Penn) School of Medicine submits this renewal application to continue and expand an innovative and successful post- doctoral training program in clinical pharmacoepidemiology (i.e., the use and effects of medications in populations). Penn promotes an academic environment in which basic and clinical research are encouraged and viewed as attractive career paths for trainees. This training program attracts clinical pharmacoepidemiology trainees from other institutions nationwide. It is anticipated that many graduates of this training program will be placed in other institutions nationwide, resulting in a program of the highest impact. The two- to three-year training program consists of required courses in clinical epidemiology, research methodology, biostatistics, pharmacoepidemiology, pharmacokinetics; elective courses in pharmacology, pharmacy practice, or other areas relevant to the trainees' interests and experience; extensive independent readings; participation in research seminars at the CCEB; clinical experiences in clinical pharmacology; and the completion of a mentored independent research project in clinical pharmacoepidemiology. The program is designed to: 1) train clinicians to be rigorous and independent academic investigators able to use the range of approaches available in epidemiology to address research issues in clinical pharmacoepidemiology related to the etiology, prognosis, prevention and early detection, treatment, clinical economics, technology assessment, medical decision making, and quality of patient care; 2) provide an understanding of the basic principles of clinical pharmacology; 3) provide intensive, supervised research experience with mentors in clinical pharmacoepidemiology; 4) provide closely mentored research experiences with faculty preceptors in clinical pharmacoepidemiology; and 5) strengthen the links between traditional epidemiology and clinical pharmacology. With the expansion of this training program, five fellowship slots will be awarded each year. Trainees matriculate in the Master of Science in Clinical Epidemiology (MSCE) degree program. Strengths of the proposed program are: 1) the large pool of extremely strong candidates seeking training in pharmacoepidemiology; 2) the long history of successful research training programs in the CCEB, including the internationally renowned clinical pharmacoepidemiology program and overlapping training in comparative effectiveness research (a new area of interest to NIH); 3) the comprehensive course offerings and research programs available to trainees; and 4) the successful training records of the program directors and faculty. In addition, the availability of the CCEB faculty, who provide expertise in a wide range of disciplines; numerous large databases useful for research projects and training; a broad array of specialized analytic capabilities available for clinical studies (e.g., clinical trials, case-control, cohort research, etc.); and the faculties' commitment to collaborative research and training, combine to provide an ideal environment for this program.