University of Miami Developmental Center for AIDS Research (D-CFAR)

描述(由申请人提供)：迈阿密大学米勒医学院建议建立一个艾滋病研究发展中心(UM D-CFAR)。UM D-CFAR的目标是成功地发展成为一个完整的CFAR，并履行NIH规定的CFAR使命，“以支持一个多学科环境，促进预防、检测和治疗艾滋病毒感染和艾滋病的基础、临床、流行病学、行为和转化性研究。”UM D-CFAR将在其优势的基础上，为NIH资助的研究活动提供基础设施，并促进旨在完成D-CFAR任务的新研究。全面领导将由Savita Pahwa博士担任，他在艾滋病毒/艾滋病领域的临床和实验室研究方面拥有丰富的经验。她将得到玛格丽特·菲舍尔博士的协助，后者将在各种临床方面和并发症研究方面提供指导。帕瓦博士将领导行政核心，以确保核心和科学研究领域之间的跨学科互动。发展核心将由Gwendolyn Scott博士领导，Gail Shor-Posner博士提供协助。他们将促进指导、新的研究活动和国际培训。已选定的共享核心是1.临床科学核心：该核心将在玛格丽特·菲舍尔博士的领导下，为D-CFAR成员提供生物统计支持和生物信息库管理。她还将在特殊队列发展和与患者安全相关的问题方面提供专业知识。2.实验室科学核心将由Savita Pahwa博士领导，Andreas Baur博士协助。这一核心将在免疫学和病毒学方面提供从常规到专门、高级和发展阶段的广泛分析。此外，一个新的组成部分是为神经艾滋病研究引入资源。3.行为/社会科学和社区外展核心将由Lisa Metsch博士和Neil Schneiderman博士领导。BSSCO核心中心将致力于加强当前的行为和社会科学艾滋病毒/艾滋病研究，并促进行为/社会科学、临床和基础科学研究人员之间更好的联系。BSSCO核心还将通过我们的D-CFAR社区咨询委员会领导D-CFAR工作和发展有意义的社区伙伴关系。在强有力的机构承诺和出色的持续研究活动的支持下，我们有信心及时过渡到全面的CFAR。 核心A：行政核心(帕瓦、萨维塔) 核心描述(由申请者提供)：行政核心将提供将迈阿密大学CFAR(UM D-CFAR)的各个组成部分联系在一起并整合在一起的基础设施。该核心的目标是为UM D-CFAR提供全面领导、行政支持、财务和业务管理以及规划职能。行政核心的具体目标是通过提供以下服务来确保中心的顺利运行和管理：1)行政领导和对所有项目和核心的监督和支持。2)促进UM D-CFAR研究人员、机构官员、国家D-CFAR社区和外部团体之间的沟通和信息传播与合作。3)协调所有D-CFAR咨询委员会的活动，包括组织一年一度的外部咨询委员会会议。4)D-CFAR的预算和财政管理以及人力资源。5)协助D-CFAR执行委员会根据正在进行的项目评价，落实优先事项和供资方面的变化。执行管理D-CFAR的政策和程序。管理D-CFAR的年度战略规划过程。6)通过支持计划开发活动的组织和实施，协助开发核心。7)准备向NIH CFAR项目工作人员提交的所有报告。8)保存记录和编写报告，包括每年提出的D-CFAR延续申请。UM D-CFAR的科学和行政领导将由该核心的首席调查员Savita Pahwa博士提供。她将由玛格丽特·菲舍尔博士协助进行临床治疗学研究。一个行政小组将由UM D-CFAR协调员(米歇尔·佩雷斯)领导。行政核心将征求外部和内部咨询委员会和执行委员会的咨询意见，并将在科学研究委员会协助开展赠款审查进程

DESCRIPTION (provided by applicant): The University of Miami, Miller School of Medicine proposes to establish a Developmental Center for AIDS Research (UM D-CFAR). The goal of the UM D-CFAR is to successfully develop into a full CFAR and fulfill the NIH stated CFAR mission "to support a multi-disciplinary environment that promotes basic, clinical, epidemiological, behavioral, and translational research in the prevention, detection, and treatment of HIV infection and AIDS." The UM D-CFAR will build on its strengths to provide the infrastructure for the NIH funded research activities and promote new research aimed at fulfilling the D-CFAR mission. The overall leadership will be provided by Dr. Savita Pahwa, who has extensive experience in clinical and laboratory research in the HIV/AIDS field. She will be assisted by Dr. Margaret Fischl, who will provide direction in various clinical aspects and complications research. Dr. Pahwa will head the Administrative Core to ensure inter-disciplinary interaction among cores and the scientific areas of research. The Developmental Core will be led by Dr Gwendolyn Scott, with assistance from Dr Gail Shor-Posner. They will promote mentoring, new research activities and international training. The shared Cores that have been selected are 1. Clinical Sciences Core: This core will be under the leadership of Dr Margaret Fischl and will offer biostatistical support and bio repository management for the D-CFAR members. She will also provide expertise in special cohort development and issues related to patient safety. 2. Laboratory Sciences Core will be led by Dr Savita Pahwa with assistance from Dr Andreas Baur. This Core will provide a broad range of assays in immunology and virology from routine to specialized, advanced and developmental. In addition a novel component is to introduce resources for Neuro-AIDS research. 3. The Behavioral/Social Sciences and Community Outreach Core (BSSCO) Core will be led by Drs. Lisa Metsch and Neil Schneiderman. The BSSCO Core will devotes its resources and expertise to enhance current behavioral and social science HIV/AIDS research and facilitate better linkages among behavioral/social science, clinical and basic science investigators. The BSSCO Core will also lead the D-CFAR in working and developing meaningful community partnerships through our D-CFAR community advisory board. Backed with a strong institutional commitment and with excellent ongoing research activities, we are confident of a timely transition into a full CFAR. CORE A: Administrative Core (Pahwa, Savita) CORE A DESCRIPTION (provided by applicant):The Administrative Core will provide the infrastructure that ties together and integrates the various components of the University of Miami CFAR (UM D-CFAR). The goal of the Core is to provide overall leadership, administrative support, financial and operational management, and planning functions for the UM D-CFAR. The specific aims of the administrative core are to insure the smooth operation and management of the center by providing the following services: 1) Administrative leadership and oversight and support for all the programs and cores. 2) Facilitation of communication and information dissemination and collaboration among UM D-CFAR researchers, institutional officials, the national D-CFAR community and external groups. 3) Coordination of the activities of all the D-CFAR advisory committees including the organization of annual External Advisory Board meeting. 4) Budgetary and fiscal management and personnel resources of the D-CFAR. 5) Assist D-CFAR Executive Committee in the implementation of changes in priorities and funding in response to ongoing project evaluation. Execution of policies and procedures that govern the D-CFAR. Management of the annual strategic planning process for the D-CFAR. 6) Assist the Developmental Core by supporting organization and implementation of program development activities. 7) Preparation of all Reports to NIH CFAR program staff. 8) Maintenance of records and preparation of reports, including the annual D-CFAR continuation application. The scientific and administrative leadership for the UM D-CFAR will be provided by Dr Savita Pahwa, the Prinicipal Investigator of this Core. She will be assisted by Dr Margaret Fischl for clinical therapeutics research. An Administrative team will be led by a UM D-CFAR Coordinator (Michelle Perez). The Administrative Core will seek advice from the External and Internal Advisory Committees and the Executive Committee, and will be assisted in the developmental grant review process by the Scientific Research Committee