CERED USF/Moffitt Transdisciplinary Center to Address Cancer Health Disparities

描述（由申请人提供）：USF-Moffitt解决癌症健康差异的跨学科中心正在提交此修订申请，以支持建立一个卓越中心，进行消除差异的比较有效性研究（CERED）。USF Moffitt CERED将进行一项关于前列腺癌筛查知情决策的比较有效性研究项目。前列腺癌代表了一个重要的癌症健康差距全国和地方在我们的社区。医疗机构一致呼吁对前列腺筛查进行知情的、个性化的决策，但目前尚不清楚这是否在通常的医疗保健环境中进行，或者替代策略是否会更有效。拟议的研究将产生重要信息，告知患者，提供者和医疗组织。此外，CERED还将利用该领域现有的优势和当前的机构努力，建立比较有效性研究的研究基础设施。修订申请利用现有的中心核心活动，教育我们的社区关于健康差异的比较有效性研究，并邀请他们参与，并增加这一领域合格研究人员的数量。拟议的CERED研究项目提供了一个机会，以促进由母公司P20倡议支持的研究，并提供生物标本，以支持针对更广泛的健康差异的比较有效性研究。莫菲特癌症中心在生物标本库（Total Cancer Care）方面拥有广泛的基础设施，并在比较有效性研究方面拥有不断扩大的基础设施。然而，由于缺乏来自少数群体的生物样本，限制了这一基础设施在解决健康差异问题方面的有效性。因此，修订版的应用活动旨在加强各机构的能力，以便针对健康差距开展有意义的比较有效性研究。

DESCRIPTION (provided by applicant): The USF-Moffitt Transdisciplinary Center to Address Cancer Health Disparities is submitting this revision application to support the establishment of a Center of Excellence for conducting Comparative Effectiveness Research for Eliminating Disparities (CERED). The USF Moffitt CERED will conduct a comparative effectiveness research project regarding informed decision making in prostate cancer screening. Prostate cancer represents an important cancer health disparity nationally and locally in our community. Medical organizations have uniformly called for informed, individualized decision making for prostate screening but it is unclear if this is currently taking place in usual medical care settings or whether alternative strategies would be more effective. The proposed study will yield important information to inform patients, providers, and medical organizations. In addition, the CERED will also build research infrastructure in Comparative Effectiveness Research leveraging existing strengths and current institutional efforts in this field. The revision application takes advantage of existing Center core activities to educate our community about comparative effectiveness research in health disparities and to invite their participation, and to increase the number of qualified researchers in this field. The proposed CERED research project provides an opportunity to promote accrual into studies supported by the parent P20 initiative and to provide biologic specimens to support comparative effectiveness studies targeting health disparities more broadly. The Moffitt Cancer Center has an extensive infrastructure in bio-specimen banking (Total Cancer Care(r)) and an expanding infrastructure in comparative effectiveness research. A paucity of bio-specimens from minority populations, however, limits the effectiveness of this infrastructure to address health disparities questions. The revision application activities are thus intended to strengthen the ability of the institutions to engage in meaningful comparative effectiveness research targeting health disparities.