Collaborative Observational Study of Myopia in COMET Children (COSMICC2)-UH

描述（由申请人提供）：本提案要求休斯顿临床中心继续按照COSMICC2方案，每年对目前在休斯顿中心登记的116名COSMICC参与者（自1997 - 1998年招募以来只有2名受试者退出）进行额外5年（总随访14年）的检查。从该中心收集的数据将用于解决主席拨款中更详细描述的具体目标，并简要总结为：1)使用数学函数（Gompers函数和其他函数）对58%的COSMICC受试者的进行性近视进展进行建模，并基于先前确定的风险因素（年龄、种族、父母近视）建立预测模型和检验假设；2)在这一特征明确的近视队列中，检验与近视进展、稳定和轴向伸长的环境危险因素相关的4个假设；3)检验COSMICC受试者IOP、CCT和黄斑厚度发生近视相关变化的三个相关危险因素的假设。近视的高患病率（占美国成人人口的25%）及其作为公共卫生的突出地位

DESCRIPTION (provided by applicant): This proposal is for the Houston Clinical Center to continue to annually examine the 116 currently enrolled COSMICC participants (only 2 subjects have withdrawn since recruited in 97-98) at the Houston center for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address specific aims described in more detail in the Chairman's grant and summarized briefly as :1)to use mathematical functions (the Gompers function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia); 2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of mopes; and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health Problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment.