Training Clincian Scientists in Neuroinfectious Disease

描述(由申请人提供)：这项新的竞争性申请请求支持在约翰霍普金斯大学建立神经感染性疾病的机构NRSA。神经系统感染是发病率和死亡率的主要原因，但目前该国没有其他侧重于神经系统感染的培训方案。我们计划开发博士后奖学金培训计划，并将提供一个特殊的培训环境。我们的培训计划通过以下各项的互动得到加强：对神经系统传染病采取跨学科的方法；重点关注服务不足的人群，包括资源有限的国家的人群；在设计以患者为中心或实验室研究时强调科学和方法的严谨性；在国内和国际上开展基于社区的合乎道德的研究的多种机会；以及在几个不同领域的广泛临床和研究专业知识。我们请求在第一年培训期间为2个博士后职位提供支持，此后增加到3个博士后职位。受训人员将进行神经感染方面的三个培训课程之一，其中包括基于实验室的研究、临床和翻译研究或国际研究。博士后培训将集中在以患者为中心或实验室领域的指导性研究，由一名教师顾问指导研究分析、论文和拨款撰写。我们为神经感染性疾病的职业培训科学家的方法将强调灵活性和基于核心课程的定制培训计划以及临床调查研究生培训计划的可用性。培训人员拥有多年成功的博士后培训和指导神经学家和其他临床科学家的经验。我们培训计划的成功将通过研究经验和广泛的研究来衡量，我们预计该计划的学员将成功竞争KOS或K23资金。这些赠款基金将为我们的神经传染病研究培训计划提供必要的核心支持。这项建议将满足培养下一代临床医生科学家的重要和关键需求。 相关性：该提案将为神经感染性疾病的临床科学家创建一个新的培训计划。神经感染性疾病是导致发病率、死亡率和长时间住院的重要原因。然而，许多此类疾病的病原学和病理生理学知之甚少，也没有可用的治疗方法。这将是该国第一个致力于培养下一代专门研究这些疾病的研究人员的项目。

DESCRIPTION (provided by applicant): This new competing application requests support for establishment of an institutional NRSA in Neurological infectious Diseases at Johns Hopkins University. Neurological infections are a major cause of morbidity and mortality yet currently there are no other training programs in the country focused on neurological infections. We plan to develop a post-doctoral fellowship training program and will provide an exceptional training environment. Our training program is strengthened by the interaction of the following: an interdisciplinary approach to neurological infectious disease; focus on underserved populations, including those in resource limited countries; emphasis on scientific and methodological rigor in the design of patient-oriented or laboratory research; diverse opportunities to conduct ethically sound, community-based research both domestically and internationally; and broad clinical and research expertise in several different areas. We are requesting support for 2 post-doctoral slots during the first year of training, increasing thereafter to 3 post-doctoral slots. The trainees will pursue one of three tracks of training in neurological infections which includes laboratory based research, clinical and translational research or international research. Post-doctoral training will focus on mentored research, either in patient-oriented or laboratory areas, with a faculty advisor guiding research analysis, paper and grant writing. Our approach to training scientists for careers in Neurological Infectious Diseases will emphasize flexibility and a customized training program based on a core curriculum and the availability of the Graduate Training Program in Clinical Investigation. Training faculty has many years of experience with successful post-doctoral training and mentoring neurologists and other clinician-scientists. The success of our training program will be measured by research experiences, plus a wide array of studies and we anticipate that trainees from this program will compete successfully for KOS or K23 funding. These grant funds will provide a core of essential support for our Neurological Infectious Disease Research Training Program. This proposal will fulfill an important and critical need for training a future generation of clinician scientists RELEVANCE: The proposal will create a new training program for clinician scientists In neuro-infectious diseases. Neuroinfectlous diseases are a significant cause of morbidity, mortality and prolonged hospitalization. Yet, the eitiology and pathophysiology of many of these disaeses is poorly understood and no treatemtment is available. This program will be the first of its kind in the country devoted to training the next generation of researchers who specialize in these diseases.